protein

RAB10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

115Connections
0Hypotheses
0Analyses
50Outgoing
49Incoming

Summary

RAB10 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Als, Alzheimer. Connected to 38 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolRAB10
Full NameRAB10, Member RAS Oncogene Family
Chromosome2p22.3
Protein FamilyRab GTPase family
FunctionRAB10 encodes a member of the Rab GTPase family involved in intracellular membrane trafficking
Subcellular LocalizationRAB10 localizes to:
Molecular Weight23 kDa
ExonsMultiple protein-coding exons spanning approximately 15 kb
PathwaysAutophagy, Mitophagy, autophagy pathway, mitophagy
UniProt IDQ9Y2P8
NCBI Gene ID10890
Ensembl IDENSG00000100705
OMIM-
GeneCardsRAB10
Human Protein AtlasRAB10
Associated DiseasesALS, Parkinson
InteractionsPARK16, LRRK2, RAB29, RAB7A, PAK1, CDC42
KG Connections115 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RAB10 — AlphaFold Q9Y2P8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

rab10 Gene

gene · 973 words

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

mechanism · 4337 words

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

mechanism · 4302 words

LRRK2 Pathway in Parkinson's Disease

mechanism · 4238 words

LRRK2 G2019S

disease · 3622 words

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

event · 3615 words

Pathway Diagram

graph TD
    RAB10["<b>RAB10</b>"]
    Als{"Als"}
    RAB10 -->|"associated with"| Als
    Parkinson{"Parkinson"}
    RAB10 -->|"activates"| Parkinson
    RAB10 -->|"regulates"| Als
    ALS{"ALS"}
    RAB10 -->|"associated with"| ALS
    RAB3A["RAB3A"]
    RAB10 -->|"associated with"| RAB3A
    Exocytosis(["Exocytosis"])
    RAB10 -->|"associated with"| Exocytosis
    PARK16["PARK16"]
    RAB10 -->|"activates"| PARK16
    RAB11B["RAB11B"]
    RAB10 -->|"associated with"| RAB11B
    RAB3C["RAB3C"]
    RAB10 -->|"associated with"| RAB3C
    RAB5A["RAB5A"]
    RAB10 -->|"associated with"| RAB5A
    RAB5["RAB5"]
    RAB10 -->|"associated with"| RAB5
    RAB27B["RAB27B"]
    RAB10 -->|"associated with"| RAB27B
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB10
    RAB27B -->|"associated with"| RAB10
    RAB3C -->|"associated with"| RAB10
    RAB5 -->|"associated with"| RAB10
    RAB3B["RAB3B"]
    RAB3B -->|"associated with"| RAB10
    RAB5A -->|"associated with"| RAB10
    RAB11B -->|"associated with"| RAB10
    RAB29["RAB29"]
    RAB29 -->|"inhibits"| RAB10
    LRRK2["LRRK2"]
    LRRK2 -->|"inhibits"| RAB10
    RAB3A -->|"associated with"| RAB10
    PARK16 -->|"activates"| RAB10
    AND["AND"]
    AND -->|"associated with"| RAB10
    style RAB10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (66)

TargetRelationTypeStr
Autophagyregulatesprocess0.85
OPTNinteracts_withprotein0.82
MITOPHAGYpromotesprocess0.80
synaptic vesicle traffickingregulatesprocess0.75
Alsassociated_withdisease0.65

Incoming (49)

SourceRelationTypeStr
PINK1interacts_withgene0.80
RAB4Bassociated_withgene0.60
RAB27Bassociated_withgene0.60
RAB3Cassociated_withgene0.60
RAB5associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found