Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB10 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Als, Alzheimer. Connected to 38 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB10 |
| Full Name | RAB10, Member RAS Oncogene Family |
| Chromosome | 2p22.3 |
| Protein Family | Rab GTPase family |
| Function | RAB10 encodes a member of the Rab GTPase family involved in intracellular membrane trafficking |
| Subcellular Localization | RAB10 localizes to: |
| Molecular Weight | 23 kDa |
| Exons | Multiple protein-coding exons spanning approximately 15 kb |
| Pathways | Autophagy, Mitophagy, autophagy pathway, mitophagy |
| UniProt ID | Q9Y2P8 |
| NCBI Gene ID | 10890 |
| Ensembl ID | ENSG00000100705 |
| OMIM | - |
| GeneCards | RAB10 |
| Human Protein Atlas | RAB10 |
| Associated Diseases | ALS, Parkinson |
| Interactions | PARK16, LRRK2, RAB29, RAB7A, PAK1, CDC42 |
| KG Connections | 115 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB10["<b>RAB10</b>"]
Als{"Als"}
RAB10 -->|"associated with"| Als
Parkinson{"Parkinson"}
RAB10 -->|"activates"| Parkinson
RAB10 -->|"regulates"| Als
ALS{"ALS"}
RAB10 -->|"associated with"| ALS
RAB3A["RAB3A"]
RAB10 -->|"associated with"| RAB3A
Exocytosis(["Exocytosis"])
RAB10 -->|"associated with"| Exocytosis
PARK16["PARK16"]
RAB10 -->|"activates"| PARK16
RAB11B["RAB11B"]
RAB10 -->|"associated with"| RAB11B
RAB3C["RAB3C"]
RAB10 -->|"associated with"| RAB3C
RAB5A["RAB5A"]
RAB10 -->|"associated with"| RAB5A
RAB5["RAB5"]
RAB10 -->|"associated with"| RAB5
RAB27B["RAB27B"]
RAB10 -->|"associated with"| RAB27B
RAB4B["RAB4B"]
RAB4B -->|"associated with"| RAB10
RAB27B -->|"associated with"| RAB10
RAB3C -->|"associated with"| RAB10
RAB5 -->|"associated with"| RAB10
RAB3B["RAB3B"]
RAB3B -->|"associated with"| RAB10
RAB5A -->|"associated with"| RAB10
RAB11B -->|"associated with"| RAB10
RAB29["RAB29"]
RAB29 -->|"inhibits"| RAB10
LRRK2["LRRK2"]
LRRK2 -->|"inhibits"| RAB10
RAB3A -->|"associated with"| RAB10
PARK16 -->|"activates"| RAB10
AND["AND"]
AND -->|"associated with"| RAB10
style RAB10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | regulates | process | 0.85 |
| OPTN | interacts_with | protein | 0.82 |
| MITOPHAGY | promotes | process | 0.80 |
| synaptic vesicle trafficking | regulates | process | 0.75 |
| Als | associated_with | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | transports | disease | 0.65 |
| ALS | phosphorylates | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Parkinson | phosphorylates | disease | 0.65 |
| RAB3A | associated_with | gene | 0.60 |
| PARK16 | activates | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| LRRK2 | inhibits | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB4B | associated_with | gene | 0.60 |
| RAB29 | inhibits | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| PAK1 | activates | gene | 0.60 |
| CDC42 | activates | gene | 0.60 |
| Synaptic Vesicle | associated_with | pathway | 0.60 |
| OPTINEURIN | activates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| OPTN | activates | gene | 0.60 |
| RAB29 | phosphorylates | entity | 0.60 |
| LRRK2 | causes | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| PARKIN | activates | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| VPS35 | expressed_in | gene | 0.60 |
| RAB12 | interacts_with | gene | 0.60 |
| RELN | interacts_with | gene | 0.60 |
| RAB12 | activates | gene | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PINK1 | interacts_with | gene | 0.80 |
| RAB4B | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB29 | inhibits | gene | 0.60 |
| LRRK2 | inhibits | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| PARK16 | activates | gene | 0.60 |
| CAV1 | regulates | gene | 0.60 |
| LRRK2 | regulates | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| PARKIN | activates | gene | 0.60 |
| PAK1 | activates | gene | 0.60 |
| LRRK2 | phosphorylates | entity | 0.60 |
| OPTINEURIN | activates | gene | 0.60 |
| OPTN | activates | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| LRRK2 | targets | gene | 0.60 |
| PINK1 | targets | gene | 0.60 |
| PRKN | targets | gene | 0.60 |
| SNCA | expressed_in | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| ATP8B1 | interacts_with | gene | 0.60 |
| CLU | interacts_with | gene | 0.60 |
| NPTX2 | interacts_with | gene | 0.60 |
| PICALM | interacts_with | gene | 0.60 |
| PLCG2 | interacts_with | gene | 0.60 |
| JIP4 | interacts_with | gene | 0.60 |
| JIP4 | activates | gene | 0.60 |
| LRRK2 | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| APOE3 | interacts_with | gene | 0.60 |
| FN1 | interacts_with | gene | 0.60 |
| PRKN | co_expressed_with | gene | 0.50 |
| PTEN | co_expressed_with | gene | 0.50 |
| MITOCHONDRIA | associated_with | cell_type | 0.50 |
| Autophagy | activates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||