entity

PE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

30Hypotheses

30Analyses

0Outgoing

1Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
ATG8	interacts_with	protein	0.72

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-Specific Lipidation Enhancement Therapy	0.845	Alzheimer's disease	-
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Dependent Microglial Senescence Transition	0.692	neurodegeneration	Gene expression changes in aging mouse b
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.674	neuroimmunology	What is the temporal sequence of TREM2 s
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode

Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.639	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Dependent Microglial Phagocytosis Acts as a Strain Sel	0.636	neurodegeneration	What are the specific molecular determin
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
CSF Biomarker-Guided ABCA7 Therapeutic Dosing	0.619	neurodegeneration	Why does the V1613M variant reduce amylo
Integrated Biomarker Panel for Therapeutic Window Identifica	0.615	neurodegeneration	What are the precise temporal dynamics o
APOE-Dependent Autophagy Restoration	0.615	neurodegeneration	Mechanistic role of APOE in neurodegener
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.614	neurodegeneration	What is the molecular mechanism by which
ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis	0.606	neurodegeneration	How does FUS loss-of-function in TAZ reg
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.600	neurodegeneration	Gene expression changes in aging mouse b
TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neur	0.584	neurodegeneration	What are the specific molecular mechanis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
Context-Dependent Cx43 Modulation Based on Disease Stage	0.579	cell biology	What is the relative contribution of con
MEF2C-Dependent Synaptic Gene Regulation	0.578	neurodegeneration	What molecular mechanisms mediate HDAC9'
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-S	0.576	neurodegeneration	What are the cell-type-specific transcri
AMPK hypersensitivity in astrocytes creates enhanced mitocho	0.570	neurodegeneration	Mitochondrial transfer between astrocyte
TREM2 Signaling Bifurcation with Independent TYROBP-Independ	0.567	neuroinflammation	Why is TYROBP deficiency neuroprotective
Competitive APOE4 Domain Stabilization Peptides	0.561	neurodegeneration	APOE4 structural biology and therapeutic
Targeted Butyrate Supplementation for Microglial Phenotype M	0.559	neurodegeneration	What are the mechanisms by which gut mic
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
SYK-Independent TREM2 Pathways Remain Functional in TYROBP D	0.555	neuroinflammation	Why is TYROBP deficiency neuroprotective
MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CN	0.552	neuropharmacology	What determines blood-brain barrier pene
CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic T	0.548	neurodegeneration	Does clusterin exacerbate or protect aga

Mentioning Analyses (30)

Scientific analyses that reference this entity

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-16 | 0 hypotheses

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

test debate

neurodegeneration | 2026-04-15 | 0 hypotheses

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793]	["Wang R", "Feng Y", "Zhou Z", "Jiang J"	Frontiers in aging neuroscienc	2026	0
Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182]	["Puerta R", "Garc\u00eda-Gonz\u00e1lez	medRxiv : the preprint server	2026	0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Molecular neurodegeneration	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412]	Villani A, Wittmann J, Wyss T, Mallona I	Commun Biol	2026	0
Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Ax [PMID:41963086]	Pottorf TS, Lane EL, Haley-Johnson Z, Uk	J Neurosci	2026	0
TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to pro [PMID:41965330]	Wang X, Zhou H, Zhai Y, Zhang Y, Cheng Y	Cell Death Discov	2026	0
Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312]	["Mehrabadi S"]	Current aging science	2026	0
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026	0
Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384]	["Siew J", "Lee C", "Chen H", "Lin H", "	Brain : a journal of neurology	2026	0
The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542]	Ahmed S, Bowers C, Munoz-Martin J, Jamwa	Brain, behavior, and immunity	2026	0
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026	0
Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial n [PMID:41881962]	Baek S, Jang J, Yeo S, Jung HJ, Choe Y	Signal transduction and target	2026	0
Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ4 [PMID:41770935]	["Konstantoulea K", "Ramakers M", "Borri	Proceedings of the National Ac	2026	0

PE

Understanding Entity Pages

Wiki Pages (20)

Device Therapies Comparison for CBS/PSP

Alpha-Synuclein Pathology

Neurons — Cell Type Hierarchy

Autophagy Mechanisms

amyloid-beta-metalloproteinases

omega-3-fatty-acids-neurodegeneration

Coenzyme Q10 for Neurodegeneration

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

fitbit

Ferroptosis in Alzheimer's Disease

Stargardt Disease

KARS1

Peroxisome Pathway in Neurodegeneration

Lipid Peroxidation in Neurodegeneration

Metabolomic Alterations in PSP

Peroxisomal Dysfunction

Ferroptosis in Neurodegeneration

Hypera Pharma

Lipid Metabolism Dysregulation in Neurodegeneration

Amyotrophic Lateral Sclerosis (ALS)

Outgoing (0)

Incoming (1)

Targeting Hypotheses (30)

Mentioning Analyses (30)

Does APOE4 drive tau propagation

Does APOE4 drive tau propagation

test debate

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

What are the specific molecular determinants that govern tau strain selection du

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Are interneuron oscillation deficits compensatory responses or primary pathologi

What are the precise temporal dynamics of astrocyte ketone production decline du

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

What upstream mechanisms trigger p53 activation specifically in response to poly

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

How does pericyte senescence mechanistically promote glioma cell growth and inva

Related Papers (20)