gene 4,033 words KG: PEN2 2026-03-24
kind:genesection:genesstate:published
Contents

PEN2 Gene

🧬 Gene Info
Gene SymbolPSENEN
AliasesPresenilin Enhancer 2
Chromosome19q13.12
Protein FamilyPEN-2 family (γ-secretase complex)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionEndoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight12 kDa
Amino Acids101 aa
PathwaysAngiogenesis
UniProt IDQ9NQ75
GeneCardsPSENEN
Human Protein AtlasPSENEN
SubunitGene
Presenilin-1 (PS1)PSEN1
Presenilin-2 (PS2)PSEN2
Associated DiseasesAD, AMI, Als, Alzheimer, Alzheimer'S Disease
InteractionsPSEN1, DAPK1, HSPG2, IL1B, APP, EIF2AK2
KG Connections98 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (23)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Dynein Motor Protein
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: implicated_in
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

PEN2 interacts_with PSEN1
PEN2 interacts_with DAPK1
PEN2 interacts_with HSPG2
PEN2 interacts_with IL1B
PEN2 interacts_with APP
PEN2 interacts_with EIF2AK2
PEN2 interacts_with APH1B
PEN2 interacts_with IL6
PEN2 interacts_with PARP1
PEN2 interacts_with HMGCR