gene 2,099 words KG: PENK 2026-03-31
kind:genesection:genesstate:published
Contents

PENK Gene

🧬 Gene Info
Gene SymbolPENK
Full NameProenkephalin
Chromosome8p11.23
Protein FamilyOpioid precursor proteins
Functionis a 267-amino acid precursor protein with a molecular weight of approximately 29 kDa.
Molecular Weight29 kDa
Amino Acids267 aa
UniProt IDP01210
NCBI Gene ID5179
Ensembl IDENSG00000100644
OMIM131330
GeneCardsPENK
Human Protein AtlasPENK
Protein ClassNeuropeptide precursor
FeaturePENK (Proenkephalin)
Associated DiseasesMs, neurodegeneration
InteractionsSST, PVALB, RGS5, CRH, EPILEPSY
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.36

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
JAG1 — Jagged 1
gene · KG edge: associated_with
ICAM5 (Intercellular Adhesion Molecule 5)
gene · KG edge: associated_with
ICAM1 - Intercellular Adhesion Molecule 1
gene · KG edge: associated_with
DRD2 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PENK expressed_in NCAM1
PENK expressed_in DNMT1
PENK expressed_in AKT1
PENK expressed_in COMT
PENK expressed_in DLGAP2
PENK expressed_in STAT3
PENK expressed_in ARG1
PENK expressed_in DRD2
PENK expressed_in DNMT3A
PENK expressed_in JAG1