protein

PKRPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKRPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PKR is one of four eIF2α kinases that comprise the integrated stress response pathway, each activated by distinct stress stimuli.

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🔬 Protein Info

Gene Symbol	PKRPROTEIN
Protein Type	Kinase
Function	is a 98 kDa serine/threonine protein kinase that plays critical roles in the cellular stress response, particularly in the integrated stress response (ISR).
Primary Expression	the brain, with particularly high levels in neurons and microglia, where it participates in both cell-autonomous and non-cell-autonomous pathogenic pr
Subcellular Localization	</strong></td><td>Cytoplasm, Nucleus</td></tr>
Molecular Weight	98 kDa
GeneCards	PKRPROTEIN
Human Protein Atlas	PKRPROTEIN
Endoplasmic reticulum stress	Through the PERK pathway (PKR shares homology with PERK, another eIF2α kinase)
Oxidative stress	Via mechanisms involving reactive oxygen species
Pro-inflammatory cytokines	Including interferon-gamma and TNF-alpha
Aggregated proteins	Including amyloid-beta and alpha-synuclein
Cellular damage signals	Including pathogen-associated molecular patterns
Associated Diseases	ALS, Alzheimer's Disease, Tau Hyperphosphorylation
Known Drugs/Compounds	Aβ(1-42), tunicamycin
Interactions	CD8, EIF2AK2, EIF2S1, G3BP1, GCN2, GSK-3Β
KG Connections	41 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PKR (Protein Kinase R)

protein · 2153 words

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Pathway Diagram

graph TD
    PKRPROTEIN["PKRPROTEIN"]
    neurodegeneration["neurodegeneration"]
    PKRPROTEIN -->|"implicated_in"| neurodegeneration
    style PKRPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning PKRPROTEIN in their description or question text

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