gene

EIF2AK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2AK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PKR (Protein Kinase R) - serine/threonine kinase activating integrated stress response in neurodegeneration

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🧬 Gene Info

Gene Symbol	EIF2AK2
Full Name	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Aliases	Protein Kinase R
Chromosome	2p22.2
Protein Family	eIF2α kinase family
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase that serves as a critical sensor of cellular stress and a key activator of the integrated stress response (ISR).
Subcellular Localization	EIF2AK2 localizes primarily to the cytoplasm:
Amino Acids	551 aa
Exons	16
Pathways	NF-κB
UniProt ID	[P19589](https://www.uniprot.org/uniprot/P19589)
Ensembl ID	ENSG00000055332
OMIM	603013
GeneCards	EIF2AK2
Human Protein Atlas	EIF2AK2
Associated Diseases	AD, AMI, Als, Alzheimer, Alzheimer's disease, RA
Interactions	LMNA, IL1B, DAPK1, HMGCR, PARP1, TNF
KG Connections	148 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EIF2AK2["EIF2AK2"]
    EIF2AK2 -->|"interacts"| Alzheimer["Alzheimer"]
    EIF2AK2 -->|"interacts"| Tumor["Tumor"]
    EIF2AK2 -->|"interacts"| Als["Als"]
    EIF2AK2 -->|"target for"| Cancer["Cancer"]
    EIF2AK2 -->|"regulates"| Ms["Ms"]
    EIF2AK2 -->|"regulates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    EIF2AK2 -->|"interacts"| ALS["ALS"]
    NCSTN["NCSTN"] -->|"interacts"| EIF2AK2
    FAS["FAS"] -->|"interacts"| EIF2AK2
    TNF["TNF"] -->|"interacts"| EIF2AK2
    LMNA["LMNA"] -->|"interacts"| EIF2AK2
    APH1B["APH1B"] -->|"interacts"| EIF2AK2
    APOE["APOE"] -->|"interacts"| EIF2AK2
    IL6["IL6"] -->|"interacts"| EIF2AK2
    SREBF1["SREBF1"] -->|"interacts"| EIF2AK2
    PSEN2["PSEN2"] -->|"interacts"| EIF2AK2
    A2M["A2M"] -->|"interacts"| EIF2AK2

Outgoing (85)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Lupus	biomarker_for	disease	0.65
Autoimmune	biomarker_for	disease	0.65
Stroke	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
LMNA	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
CREBBP	regulates	gene	0.60
DYNEIN	interacts_with	gene	0.60
HIF1A	therapeutic_target	gene	0.60
FOXO3	inhibits	gene	0.60
CTSL	therapeutic_target	gene	0.60
PIK3C3	therapeutic_target	gene	0.60
BECN1	therapeutic_target	gene	0.60
BNIP3	therapeutic_target	gene	0.60
STAT3	inhibits	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
DHCR24	interacts_with	gene	0.60
Dynein	interacts_with	protein	0.60
Kinesin	interacts_with	protein	0.60
FCER1G	activates	gene	0.60
EIF2S1	activates	gene	0.60
Cholesterol	interacts_with	pathway	0.60

Incoming (63)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
HSV-1	inhibits	entity	0.80
NCSTN	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
BNIP3	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
CTSL	therapeutic_target	gene	0.60
FOXO3	inhibits	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
BECN1	therapeutic_target	gene	0.60
STAT3	inhibits	gene	0.60
CTSB	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
FOXO1	inhibits	gene	0.60
PIK3C3	therapeutic_target	gene	0.60
PIK3CA	regulates	gene	0.60
CD44	regulates	gene	0.60
SRC	regulates	gene	0.60
EEF2	regulates	gene	0.60
SOD1	regulates	gene	0.60
FZD9	regulates	gene	0.60
FZD2	regulates	gene	0.60
GRB2	regulates	gene	0.60
DYNEIN	interacts_with	gene	0.60
BCL2 FAMILY	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
AUTOPHAGY-RELATED GENES	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
MOTOR NEURONS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EIF2AK2

Understanding Entity Pages

Summary

Wiki Pages (17)

EIF2AK2 — Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2

PKR Pathway in Neurodegeneration

Integrated Stress Response in Neurodegeneration

PKR (Protein Kinase R)

A2M Gene

Stress Granule Dynamics in Neurodegeneration

ISR Modulator Therapy

PEN2 Protein

FZD9 Gene

PKR Protein (Protein Kinase R)

EIF2α Protein

Presenilin Enhancer 2 (PEN-2) Protein

EEF1G — Eukaryotic Translation Elongation Factor 1 Gamma

EIF2S1 (eIF2α)