concept

GCN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

183Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GCN2
Key Genes/Proteins	PRKAA2, MAPK14, BECN1
Related Diseases	amino acid insufficiency, Cancer, ALS, Fibrosis, Neurodegeneration
Related Pathways	Integrated Stress Response

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GCN2["GCN2"]
    GCN2 -->|"involved_in"| Integrated_Stress_Response["Integrated Stress Response"]
    GCN2 -->|"interacts"| Cancer["Cancer"]
    GCN2 -->|"interacts"| ALS["ALS"]
    GCN2 -->|"interacts"| Fibrosis["Fibrosis"]
    GCN2 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    Identified_Compounds["Identified Compounds"] -->|"targets"| GCN2
    ISR_Potentiators["ISR Potentiators"] -->|"targets"| GCN2
    LC3["LC3"] -->|"interacts"| GCN2
    CALCOCO2["CALCOCO2"] -->|"interacts"| GCN2
    ERN1["ERN1"] -->|"interacts"| GCN2
    LRRK2["LRRK2"] -->|"interacts"| GCN2
    WNT["WNT"] -->|"interacts"| GCN2
    RB1["RB1"] -->|"interacts"| GCN2

Outgoing (117)

Target	Relation	Type	Str
Integrated Stress Response	involved_in	pathway	0.90
PRKAA2	phosphorylates	gene	0.90
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	activates	disease	0.65
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Mtor	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Oxidative Phosphorylation	interacts_with	pathway	0.60
Wnt	interacts_with	pathway	0.60
Apoptosis	activates	pathway	0.60
AND	activates	gene	0.60

Incoming (66)

Source	Relation	Type	Str
Identified Compounds	targets	compound	0.90
ISR Potentiators	targets	compound	0.88
amino acid insufficiency	activates	phenotype	0.85
LC3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
CYP1A1	interacts_with	gene	0.60
ATF4	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
P53	activates	gene	0.60
DNA	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
AND	inhibits	gene	0.60
CANCER	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GCN2

Understanding Entity Pages

Wiki Pages (20)

er-stress-neurodegeneration

Unfolded Protein Response (UPR)

PKR Pathway in Neurodegeneration

Stress Granules in Neurodegeneration

Stress Granule Dysfunction Hypothesis in Parkinson's Disease

Mitochondrial Unfolded Protein Response in Neurodegeneration

RAN Translation in Neurodegeneration

Stress Granules in Neurodegeneration

PPP1R15B

proteostasis-triad-pulses

Integrated Stress Response in Alzheimer's Disease

Liquid-Liquid Phase Separation

eIF4G1 Protein

Protein Synthesis in Neurodegenerative Diseases

Integrated Stress Response in Neurodegeneration

chop

Stress Granules and RNA Granules in Neurodegeneration

Vanishing White Matter Disease (VWM)