concept

GCN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

182Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	GCN2
Key Genes/Proteins	AKT1, AKT1S1, AMBRA1, AMPK, AMPKα2, AND
Related Diseases	ALS, amino acid insufficiency
Related Pathways	Apoptosis, apoptosis pathway

Pathway Diagram

graph TD
    GCN2["GCN2"]
    GCN2 -->|"involved_in"| Integrated_Stress_Response["Integrated Stress Response"]
    GCN2 -->|"interacts"| Cancer["Cancer"]
    GCN2 -->|"interacts"| ALS["ALS"]
    GCN2 -->|"interacts"| Fibrosis["Fibrosis"]
    GCN2 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    Identified_Compounds["Identified Compounds"] -->|"targets"| GCN2
    ISR_Potentiators["ISR Potentiators"] -->|"targets"| GCN2
    LC3["LC3"] -->|"interacts"| GCN2
    CALCOCO2["CALCOCO2"] -->|"interacts"| GCN2
    ERN1["ERN1"] -->|"interacts"| GCN2
    LRRK2["LRRK2"] -->|"interacts"| GCN2
    WNT["WNT"] -->|"interacts"| GCN2
    RB1["RB1"] -->|"interacts"| GCN2

Outgoing (117)

Target	Relation	Type	Str
PRKAA2	phosphorylates	gene	0.90
Integrated Stress Response	involved_in	pathway	0.90
AMPKα2	associated_with	gene	0.90
eIF2α phosphorylation	activates	phenotype	0.70
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
APOPTOSIS	mediates	process	0.60
RB1CC1	interacts_with	gene	0.60
Apoptosis	activates	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
JNK	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
GRB2	activates	gene	0.60
HMGB1	activates	gene	0.60
HSPA5	activates	gene	0.60
IFN	activates	gene	0.60
IFNG	activates	gene	0.60
JNK	activates	gene	0.60
LC3	activates	gene	0.60
LRRK2	activates	gene	0.60
MAP1LC3A	activates	gene	0.60
MAPK	activates	gene	0.60
MAPK14	activates	gene	0.60
MAVS	activates	gene	0.60
MLKL	activates	gene	0.60
MLST8	activates	gene	0.60
MTOR	activates	gene	0.60
MTORC1	activates	gene	0.60
NBR1	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
OPTN	activates	gene	0.60
PI3K	activates	gene	0.60

Incoming (65)

Source	Relation	Type	Str
Identified Compounds	targets	compound	0.90
ISR Potentiators	targets	compound	0.88
amino acid insufficiency	activates	phenotype	0.85
LC3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
P53	activates	gene	0.60
MLST8	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
CYP1A1	interacts_with	gene	0.60
DNA	activates	gene	0.60
CYP1A1	activates	gene	0.60
DDIT3	activates	gene	0.60
DEPTOR	activates	gene	0.60
EGF	activates	gene	0.60
EGFR	activates	gene	0.60
EIF2A	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ERN1	activates	gene	0.60
FIP200	activates	gene	0.60
GABA	activates	gene	0.60
DEPTOR	interacts_with	gene	0.60
GABARAP	activates	gene	0.60
DDIT3	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
RAS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the temporal transition from protective to pathological stress g

neurodegeneration | 2026-04-12 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed that stress granules can be both neuroprotective and patholo

closed · Rounds: 4 · Score: 0.86 · 2026-04-16

Related Research

Hypotheses and analyses mentioning GCN2 in their description or question text

No additional research found