Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TAU HYPERPHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TAU HYPERPHOSPHORYLATION |
Knowledge base pages for this entity
graph TD
TAU_HYPERPHOSPHORYLATION["TAU HYPERPHOSPHORYLATION"]
TAU_HYPERPHOSPHORYLATION -->|"contributes to"| Tau_Aggregation["Tau Aggregation"]
TAU_HYPERPHOSPHORYLATION -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
MAPT["MAPT"] -->|"involved_in"| TAU_HYPERPHOSPHORYLATION
Exendin_4["Exendin-4"] -->|"inhibits"| TAU_HYPERPHOSPHORYLATION
ASK1["ASK1"] -->|"causes"| TAU_HYPERPHOSPHORYLATION
Wnt___catenin_NeuroD1_Pathway["Wnt/beta-catenin/NeuroD1 Pathway"] -->|"regulates"| TAU_HYPERPHOSPHORYLATION
Neuroinflammation["Neuroinflammation"] -->|"contributes to"| TAU_HYPERPHOSPHORYLATION
HEPATOKINES["HEPATOKINES"] -->|"regulates"| TAU_HYPERPHOSPHORYLATION| Target | Relation | Type | Str |
|---|---|---|---|
| Neurofibrillary Tangles | causes | biomarker | 0.95 |
| Alzheimer's Disease | associated_with | disease | 0.95 |
| Paired Helical Filaments | causes | biomarker | 0.90 |
| Synaptic Toxicity | associated_with | phenotype | 0.90 |
| Cognitive Impairments | associated_with | phenotype | 0.90 |
| Alzheimer'S Disease | biomarker_for | disease | 0.90 |
| Tauopathies | biomarker_for | disease | 0.90 |
| Neurodegeneration | contributes_to | process | 0.90 |
| Alzheimer's Disease | drives | disease | 0.90 |
| Tau Aggregation | contributes_to | process | 0.85 |
| tau O-GlcNAc protection | suppresses | process | 0.85 |
| Type 2 Diabetes | associated_with | disease | 0.85 |
| Alzheimer'S Disease | contributes_to | disease | 0.85 |
| Alzheimer's Disease | contributes_to | disease | 0.85 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Alzheimer's disease | causes | disease | 0.70 |
| Alzheimer's disease | causes | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | involved_in | protein | 0.95 |
| GSK3B | involved_in | gene | 0.95 |
| PPP2CA | regulates | gene | 0.95 |
| DAB | causes | compound | 0.95 |
| Exendin-4 | inhibits | drug | 0.90 |
| Air Pollution | causes | compound | 0.90 |
| MAPT MUTATION | causes | gene | 0.90 |
| Sulforaphane | inhibits | compound | 0.90 |
| Ampk Activation | promotes | process | 0.90 |
| PKR | causes | entity | 0.90 |
| Wnt/β-catenin/NeuroD1 Pathway | regulates | pathway | 0.85 |
| APOE4 | risk_factor_for | gene | 0.85 |
| Ceramide | contributes_to | compound | 0.85 |
| MTOR | promotes | gene | 0.85 |
| ASK1 | causes | protein | 0.85 |
| Platelets | associated_with | cell_type | 0.85 |
| ASK1 | mediates | protein | 0.85 |
| Tau Kinase Inhibitors | inhibits | drug | 0.85 |
| HEPATOKINES | regulates | protein | 0.80 |
| miR-125b | contributes_to | biomarker | 0.80 |
| miR-132 | inhibits | biomarker | 0.80 |
| GSK3B | mediates | gene | 0.80 |
| ceramide | causes | metabolite | 0.80 |
| Neuroinflammation | contributes_to | process | 0.80 |
| ASK1 | contributes_to | protein | 0.80 |
| Insulin Signaling | inhibits | pathway | 0.80 |
| MTOR | activates | protein | 0.70 |
| Indoles | protects_against | process | 0.70 |
| BMAL1 | protects_against | gene | 0.70 |
| Exendin-4 | inhibits | drug | 0.70 |
| mTOR | activates | protein | 0.70 |
| GSK3β | activates | protein | 0.70 |
| GSK-3 | regulates | protein | 0.70 |
| SLC1A2 | contributes_to | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||