concept

EIF2S1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2S1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

468Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

EIF2S1 is a concept in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with AD, ALI, Als. Connected to 213 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameEIF2S1
SummaryEIF2S1 encodes eIF2α, the master regulator of the integrated stress response and protein synthesis. Phosphorylation at Ser51 triggers global translation arrest while allowing selective stress gene expression.
Related DiseasesDementia, Cardiovascular, Als, Alzheimer, Parkinson

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

EIF2S1 (eIF2α)

gene · 673 words

PKR Pathway in Neurodegeneration

mechanism · 3254 words

PPP1R15B

gene · 2982 words

Presenilin-1 (PS1)

entity · 1985 words

Hepsin Protein

protein · 1933 words

RNA Metabolism Dysfunction in Corticobasal Syndrome

mechanism · 1903 words

Pathway Diagram

graph TD
    EIF2S1["EIF2S1"]
    EIF2S1 -->|"interacts"| Dementia["Dementia"]
    EIF2S1 -->|"interacts"| Cardiovascular["Cardiovascular"]
    EIF2S1 -->|"interacts"| Als["Als"]
    EIF2S1 -->|"interacts"| Alzheimer["Alzheimer"]
    EIF2S1 -->|"interacts"| Parkinson["Parkinson"]
    EIF2S1 -->|"interacts"| Ms["Ms"]
    EIF2S1 -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    EIF2S1 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    EIF2S1 -->|"interacts"| Ftd["Ftd"]
    CAT["CAT"] -->|"interacts"| EIF2S1
    OPTN["OPTN"] -->|"interacts"| EIF2S1
    DNM1L["DNM1L"] -->|"interacts"| EIF2S1
    CANX["CANX"] -->|"interacts"| EIF2S1
    LGALS3["LGALS3"] -->|"interacts"| EIF2S1
    CALCOCO2["CALCOCO2"] -->|"interacts"| EIF2S1
    G3BP1["G3BP1"] -->|"interacts"| EIF2S1
    PEX3["PEX3"] -->|"interacts"| EIF2S1
    SQSTM1["SQSTM1"] -->|"interacts"| EIF2S1
    BCL2["BCL2"] -->|"interacts"| EIF2S1

Outgoing (252)

TargetRelationTypeStr
Dementiainteracts_withdisease0.65
Cardiovascularinteracts_withdisease0.65
Alsinteracts_withdisease0.65
Alzheimerinteracts_withdisease0.65
Parkinsoninteracts_withdisease0.65

Incoming (216)

SourceRelationTypeStr
CATinteracts_withgene0.60
OPTNinteracts_withgene0.60
DNM1Linteracts_withgene0.60
CANXinteracts_withgene0.60
LGALS3interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found