Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EIF2S1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EIF2S1 is a concept in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with AD, ALI, Als. Connected to 213 entities in the SciDEX knowledge graph.
| Name | EIF2S1 |
| Summary | EIF2S1 encodes eIF2α, the master regulator of the integrated stress response and protein synthesis. Phosphorylation at Ser51 triggers global translation arrest while allowing selective stress gene expression. |
| Related Diseases | Dementia, Cardiovascular, Als, Alzheimer, Parkinson |
Knowledge base pages for this entity
graph TD
EIF2S1["EIF2S1"]
EIF2S1 -->|"interacts"| Dementia["Dementia"]
EIF2S1 -->|"interacts"| Cardiovascular["Cardiovascular"]
EIF2S1 -->|"interacts"| Als["Als"]
EIF2S1 -->|"interacts"| Alzheimer["Alzheimer"]
EIF2S1 -->|"interacts"| Parkinson["Parkinson"]
EIF2S1 -->|"interacts"| Ms["Ms"]
EIF2S1 -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
EIF2S1 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
EIF2S1 -->|"interacts"| Ftd["Ftd"]
CAT["CAT"] -->|"interacts"| EIF2S1
OPTN["OPTN"] -->|"interacts"| EIF2S1
DNM1L["DNM1L"] -->|"interacts"| EIF2S1
CANX["CANX"] -->|"interacts"| EIF2S1
LGALS3["LGALS3"] -->|"interacts"| EIF2S1
CALCOCO2["CALCOCO2"] -->|"interacts"| EIF2S1
G3BP1["G3BP1"] -->|"interacts"| EIF2S1
PEX3["PEX3"] -->|"interacts"| EIF2S1
SQSTM1["SQSTM1"] -->|"interacts"| EIF2S1
BCL2["BCL2"] -->|"interacts"| EIF2S1| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | interacts_with | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Ftd | interacts_with | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Ischemia | associated_with | disease | 0.65 |
| RIPK3 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| FUNDC1 | interacts_with | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| BCL2L13 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| RTN3 | interacts_with | gene | 0.60 |
| SESN2 | interacts_with | gene | 0.60 |
| CAT | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| TFE3 | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| PERK | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| SESN2 | interacts_with | gene | 0.60 |
| BCL2L13 | interacts_with | gene | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||