gene

PNP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PNP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

7Outgoing

2Incoming

0Experiments

0Debates

Summary

PNP is a gene implicated in neurodegeneration research. Key relationships include: inhibits, interacts with, activates. Associated with Inflammation, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PNP
Full Name	Purine Nucleoside Phosphorylase
Chromosome	14q11.2
Protein Type	Enzyme
Function	This reaction is essential for purine salvage and recycling.
Primary Expression	neurons and glial cells where it participates in purinergic signaling
Molecular Weight	32 kDa
UniProt ID	P00491
NCBI Gene ID	4860
Ensembl ID	ENSG00000112919
OMIM	164050
GeneCards	PNP
Human Protein Atlas	PNP
Associated Diseases	Ms
Interactions	AMPK, INFLAMMATION, JAK2, STAT3
KG Connections	9 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PNP — AlphaFold P00491 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PNP["PNP"]
    Inflammation{"Inflammation"}
    PNP -->|"inhibits"| Inflammation
    Ms{"Ms"}
    PNP -->|"associated with"| Ms
    PNP -->|"activates"| Ms
    PNP -->|"interacts with"| Inflammation
    Endocytosis(["Endocytosis"])
    PNP -->|"inhibits"| Endocytosis
    AMPK["AMPK"]
    PNP -->|"activates"| AMPK
    INFLAMMATION["INFLAMMATION"]
    PNP -->|"interacts with"| INFLAMMATION
    neurodegeneration["neurodegeneration"]
    PNP -->|"implicated in"| neurodegeneration
    JAK2["JAK2"]
    JAK2 -->|"inhibits"| PNP
    STAT3["STAT3"]
    STAT3 -->|"inhibits"| PNP
    style PNP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Endocytosis	inhibits	pathway	0.60
AMPK	activates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
JAK2	inhibits	gene	0.60
STAT3	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PNP in their description or question text

No additional research found

PNP