PS

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Does tau aggregation specifically cause PS externalization in vesicles independe

neurodegeneration | 2026-04-11 | 0 hypotheses

Does tau aggregation specifically cause PS externalization in living cells versu

neurodegeneration | 2026-04-10 | 7 hypotheses

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.732

What are the biophysical determinants — RNA binding stoichiometry, post-translat

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

What is the precise causal sequence of molecular events linking TDP-43 nuclear c

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

Which proteogenomic network hubs identified by multi-omics PD studies are drugga

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

closed · Rounds: 4 · Score: 0.79 · 2026-04-21

The debate identified a critical gap in understanding whether PS exposure is tau

closed · Rounds: 4 · Score: 0.44 · 2026-04-21

The debate revealed a fundamental gap in understanding whether tau pathology dir

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

closed · Rounds: 4 · Score: 0.84 · 2026-04-16

The study shows PSEN2 is essential in cortical and dopaminergic neurons and regu

closed · Rounds: 4 · Score: 0.68 · 2026-04-16

Both compounds similarly reduced aging hallmarks (AMPK, Nrf2, COX IV1) and infla

closed · Rounds: 4 · Score: 0.68 · 2026-04-16

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 4 · Score: 0.69 · 2026-04-12

CX3CR1-TREM2 Integration for Synapse Pruning Normalization

Score: 0.776 · neurodegeneration · 2026-04-16

## Mechanistic Overview CX3CR1-TREM2 Integration for Synapse Pruning Normalization starts from the claim that modulating

Lysosomal Cathepsin-Dependent Tau Clearance

Score: 0.767 · neurodegeneration · 2026-04-17

## Mechanistic Overview Lysosomal Cathepsin-Dependent Tau Clearance starts from the claim that modulating not yet specif

SASP-Mediated Cholinergic Synapse Disruption

Score: 0.763 · neurodegeneration · 2026-04-02

## Mechanistic Overview SASP-Mediated Cholinergic Synapse Disruption starts from the claim that modulating MMP2/MMP9 wit

PARP1-NAD+-AIF bioenergetic collapse drives a self-amplifying parthanatos loop

Score: 0.760 · neurodegeneration · 2026-04-25

Oxidative DNA damage hyperactivates PARP1, rapidly consuming NAD+ and collapsing ATP production. Bioenergetic failure im

VPS35 retromer activation prevents endosomal tau templating across all brain reg

Score: 0.740 · neurodegeneration · 2026-04-21

## Mechanistic Overview VPS35 retromer activation prevents endosomal tau templating across all brain regions and disease

H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules

Score: 0.737 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The central molecular mechanism underlying this hypothesis involves the intricate

H1: T-Type Calcium Channel–Driven Calcium Overload and Proteostasis Collapse

Score: 0.730 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The pathophysiology of neurodegeneration in layer II stellate cells centers on dy

Endosomal trafficking defects are the common upstream lesion linking APP process

Score: 0.730 · neurodegeneration · 2026-04-25

AD-risk trafficking defects in SORL1/BIN1/PICALM/retromer may generate parallel early outputs: amyloidogenic APP sorting

TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I

Score: 0.724 · neurodegeneration · 2026-04-13

**Molecular Mechanism and Rationale** The molecular cascade underlying TBK1 loss-of-function-mediated synapse eliminati

APOE4-driven pericyte injury/senescence is an upstream driver of early BBB break

Score: 0.720 · neurodegeneration · 2026-04-25

In APOE4 contexts, reduced LRP1 signaling in PDGFRB+ pericytes permits activation of the PPIA/CypA-MMP9 axis, leading to

TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut-Brain Neuroinflamma

Score: 0.703 · neurodegeneration · 2026-04-16

**Molecular Mechanism and Rationale** The pathogenesis of Parkinson's disease (PD) involves complex interactions betwee

CCL2-CCR2 Driven Macrophage Infiltration Selectively Strips Fast-Fatigable NMJs

Score: 0.682 · als · 2026-04-27

CCR2+ monocyte-derived macrophages, recruited to the neuromuscular junction by motor neuron-secreted CCL2, selectively i