concept

CKLF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CKLF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

0Experiments

0Debates

Summary

CKLF1 is a concept in neurodegeneration research. Key relationships include: activates, interacts with, contributes to. Associated with ALS, Als, Inflammation. Connected to 79 entities in the SciDEX knowledge graph.

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Pathway Diagram

graph TD
    CKLF1["CKLF1"]
    CKLF1 -->|"causes"| microglial_activation["microglial activation"]
    CKLF1 -->|"contributes to"| DNM1L["DNM1L"]
    CKLF1 -->|"contributes to"| PINK1["PINK1"]
    CKLF1 -->|"contributes to"| PRKN["PRKN"]
    CKLF1 -->|"contributes to"| MAP1LC3B["MAP1LC3B"]
    CKLF1 -->|"contributes to"| BECN1["BECN1"]
    CKLF1 -->|"contributes to"| SQSTM1["SQSTM1"]
    CKLF1 -->|"interacts"| PS["PS"]
    CKLF1 -->|"interacts"| Stroke["Stroke"]
    CKLF1 -->|"activates"| Als["Als"]
    TFEB["TFEB"] -->|"activates"| CKLF1
    DNM1L -->|"activates"| CKLF1
    SQSTM1 -->|"activates"| CKLF1
    PTEN["PTEN"] -->|"activates"| CKLF1
    OPTN["OPTN"] -->|"activates"| CKLF1
    MAP1LC3B -->|"activates"| CKLF1
    PINK1 -->|"activates"| CKLF1
    PRKN -->|"activates"| CKLF1
    AIF1["AIF1"] -->|"activates"| CKLF1
    MITOPHAGY["MITOPHAGY"] -->|"activates"| CKLF1

Outgoing (81)

Target	Relation	Type	Str
microglial activation	causes	phenotype	0.90
phosphatidylserine	binds_to	compound	0.90
PINK1	contributes_to	gene	0.80
PRKN	contributes_to	gene	0.80
MAP1LC3B	contributes_to	gene	0.80
BECN1	contributes_to	gene	0.80
SQSTM1	contributes_to	gene	0.80
microglial recruitment	promotes	process	0.80
DNM1L	contributes_to	gene	0.80
microglia	expressed_in	cell_type	0.80
Als	activates	disease	0.75
PS	interacts_with	protein	0.72
ALS	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Stroke	interacts_with	disease	0.65
CCR4	activates	protein	0.64
IL6	activates	protein	0.64
EFFEROCYTOSIS	inhibits	phenotype	0.64
stroke	inhibits	disease	0.60
RAS	activates	gene	0.60
IL6	causes	gene	0.60
HIF	inhibits	gene	0.60
VEGF	inhibits	gene	0.60
HIF	activates	gene	0.60
RNA	expressed_in	gene	0.60
stroke	associated_with	disease	0.60
stroke	implicated_in	disease	0.60
HIF	regulates	gene	0.60
VEGF	regulates	gene	0.60
stroke	regulates	disease	0.60
HIF	expressed_in	gene	0.60
VEGF	expressed_in	gene	0.60
RAC1	activates	gene	0.60
STAT3	activates	gene	0.60
Notch signaling	participates_in	pathway	0.60
Mitophagy	activates	pathway	0.60
IL6	associated_with	gene	0.60
TFEB	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
MICROGLIA	interacts_with	gene	0.60
STROKE	interacts_with	gene	0.60
AND	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
Interleukin	causes	protein	0.60

Incoming (39)

Source	Relation	Type	Str
IL6	associated_with	gene	0.60
TFEB	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
CYTOKINES	activates	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60
BECN1	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
IL6	causes	gene	0.60
AMPK	activates	gene	0.60
rapamycin	targets	drug	0.60
PYROPTOSIS	activates	gene	0.60
CCR5	activates	gene	0.60
NF-ΚB	activates	gene	0.60
CKLF	activates	gene	0.60
RAS	activates	gene	0.60
STAT3	activates	gene	0.60
LYSOSOME	activates	gene	0.60
AND	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DNM1L	activates	gene	0.60
SQSTM1	activates	gene	0.60
PTEN	activates	gene	0.60
OPTN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
AIF1	activates	gene	0.60
RAC1	activates	gene	0.60
STROKE	interacts_with	gene	0.60
MICROGLIA	interacts_with	gene	0.60
CCR5	expressed_in	gene	0.60
Neuroinflammation	activates	process	0.50
mitophagy	activates	pathway	0.50
microglia	activates	cell_type	0.50
NEURONS	interacts_with	concept	0.50
microglia	causes	cell_type	0.50
microglia	interacts_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity