gene

QRFP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about QRFP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

18Outgoing

2Incoming

Summary

Page for QRFP Gene

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🧬 Gene Info

Gene Symbol	QRFP
Full Name	Glutaminyl RFamide Peptide Receptor
Aliases	QRFPR, PNQALIDE, QRPQR
Chromosome	4q21.31
Protein Family	G protein-coupled receptor, Rhodopsin family
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the hypothalamus, particularly in the arcuate nucleus and paraventricular nucleus, as well as in the brainstem and spinal cord[@takayasu2008][@kim2014
Amino Acids	366 aa
OMIM	607442
GeneCards	QRFP
Human Protein Atlas	QRFP
Protein	QRFPR (Pyroglutamylated RFamide peptide receptor)
Associated Diseases	ALS, Autoimmune
KG Connections	20 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["QRFP"]
    N1["Als"]
    N0 -->|"biomarker for"| N1
    N2["ALS"]
    N0 -->|"causes"| N2
    N3["Autoimmune"]
    N0 -->|"causes"| N3
    N4["Sleep Disorder"]
    N0 -->|"inhibits"| N4
    N0 -->|"inhibits"| N1
    N5["HCRT"]
    N0 -->|"biomarker for"| N5
    N6["Epigenetic"]
    N0 -->|"biomarker for"| N6
    N7["T Cell"]
    N0 -->|"biomarker for"| N7
    N8["Neuron"]
    N0 -->|"biomarker for"| N8
    N9["AND"]
    N0 -->|"causes"| N9
    N10["CRH"]
    N0 -->|"causes"| N10
    N0 -->|"causes"| N6
    N0 -->|"inhibits"| N6
    N5 -->|"biomarker for"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 gene
    class N6 pathway
    class N9 gene
    class N10 gene

Outgoing (18)

Target	Relation	Type	Str
Sleep Disorder	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
ALS	causes	disease	0.65
Autoimmune	causes	disease	0.65
Als	inhibits	disease	0.65
HCRT	biomarker_for	gene	0.60
CRH	causes	gene	0.60
Epigenetic	biomarker_for	pathway	0.60
T Cell	biomarker_for	cell_type	0.60
Neuron	biomarker_for	cell_type	0.60
AND	causes	gene	0.60
Epigenetic	causes	pathway	0.60
Epigenetic	inhibits	pathway	0.60
neurons	expressed_in	cell_type	0.60
T Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
HCRT	associated_with	concept	0.50
NEURONS	associated_with	concept	0.50

Incoming (2)

Source	Relation	Type	Str
HCRT	biomarker_for	gene	0.60
HCRT	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found