disease

Autoimmune

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Autoimmune: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1590Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Autoimmune is a disease characterized by neurodegeneration research. Key relationships include: therapeutic target, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 1193 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	MOG, P2RX7, CD19, GENES, G6PD, STING, CGAS, DSDNA
KG Connections	1590 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Autoimmune["Autoimmune"] -->|"regulates"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Autoimmune["Autoimmune"] -.->|"inhibits"| Lysosomal_Degradation["Lysosomal Degradation"]
    Autoimmune["Autoimmune"] -.->|"inhibits"| Blood_Brain_Barrier_1["Blood-Brain Barrier"]
    Autoimmune["Autoimmune"] -->|"therapeutic target"| Complement["Complement"]
    Autoimmune["Autoimmune"] -->|"therapeutic target"| Autophagy["Autophagy"]
    Autoimmune["Autoimmune"] -->|"therapeutic target"| Ferroptosis["Ferroptosis"]
    CD40["CD40"] -->|"expressed in"| Autoimmune["Autoimmune"]
    AQP4["AQP4"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    PARP1["PARP1"] -->|"regulates"| Autoimmune["Autoimmune"]
    FCGRT["FCGRT"] -->|"regulates"| Autoimmune["Autoimmune"]
    style Autoimmune fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (474)

Target	Relation	Type	Str
Inflammation	associated_with	disease	1.00
Immune Response	activates	pathway	1.00
Innate Immunity	activates	pathway	1.00
Immune Response	regulates	pathway	1.00
Nf-Κb	therapeutic_target	pathway	1.00
Immune Response	therapeutic_target	pathway	1.00
Cancer	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Als	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Cancer	activates	disease	1.00
Differentiation	therapeutic_target	pathway	1.00
Rheumatoid Arthritis	associated_with	disease	1.00
Als	activates	disease	1.00
Nf-Κb	activates	pathway	1.00
Immune Response	causes	pathway	1.00
Inflammation	regulates	disease	1.00
Als	regulates	disease	1.00
Immunotherapy	therapeutic_target	pathway	1.00
Differentiation	activates	pathway	1.00
Immune Response	implicated_in	pathway	1.00
Multiple Sclerosis	associated_with	disease	0.95
Inflammation	inhibits	disease	0.95
Neurodegeneration	activates	disease	0.95
Autophagy	therapeutic_target	pathway	0.90
Apoptosis	activates	pathway	0.90
Autophagy	regulates	pathway	0.90
Stem Cell	therapeutic_target	pathway	0.90
Apoptosis	associated_with	pathway	0.90
Differentiation	regulates	pathway	0.90
Tgf-Β	therapeutic_target	pathway	0.90
Infection	therapeutic_target	disease	0.85
Cancer	causes	disease	0.85
Inflammation	causes	disease	0.85
Cancer	regulates	disease	0.85
Als	inhibits	disease	0.85
Cancer	therapeutic_target	disease	0.85
Neurodegeneration	regulates	disease	0.85
Blood-Brain Barrier	activates	pathway	0.80
Oxidative Stress	regulates	pathway	0.80
Apoptosis	regulates	pathway	0.80
Mtor	therapeutic_target	pathway	0.80
Mtor	activates	pathway	0.80
Epigenetic	activates	pathway	0.80
Glycolysis	activates	pathway	0.80
Inflammasome	activates	pathway	0.80
Autophagy	implicated_in	pathway	0.80
Epigenetic	therapeutic_target	pathway	0.80
Senescence	activates	pathway	0.80

Incoming (1116)

Source	Relation	Type	Str
CGAS	activates	gene	1.00
Cancer	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
GENES	activates	gene	1.00
DNA	regulates	gene	1.00
OVERVIEW	therapeutic_target	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
CYTOKINES	therapeutic_target	gene	1.00
NF-ΚB	therapeutic_target	gene	1.00
ASTROCYTES	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
CANCER	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
CYTOKINES	regulates	gene	1.00
CANCER	regulates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
CANCER	therapeutic_target	gene	1.00
NEURODEGENERATION	activates	gene	1.00
STAT3	activates	gene	1.00
IL-6	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
CYTOKINES	activates	gene	1.00
NF-ΚB	activates	gene	1.00
IL-6	therapeutic_target	gene	1.00
MICROGLIA	activates	gene	1.00
GENES	regulates	gene	1.00
Tumor	activates	disease	1.00
Infection	activates	disease	1.00
Inflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	causes	gene	1.00
CANCER	implicated_in	gene	1.00
INFLAMMATION	causes	gene	1.00
Als	activates	disease	1.00
MIRNAS	regulates	gene	1.00
GENES	therapeutic_target	gene	0.95
DNA	activates	gene	0.95
STAT3	therapeutic_target	gene	0.95
GENES	associated_with	gene	0.95
APOPTOSIS	activates	gene	0.95
JAK	therapeutic_target	gene	0.95
AUTOPHAGY	regulates	gene	0.95
CGAS-STING	activates	gene	0.95
APOPTOSIS	regulates	gene	0.95
APOPTOSIS	therapeutic_target	gene	0.95
BCL-2	therapeutic_target	gene	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Autoimmune

Understanding Entity Pages

Summary

Wiki Pages (21)

Autoimmune Hypothesis in Alzheimer's Disease

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

neuroinflammation

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

williams-syndrome

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

Kabuki Syndrome

TREM2 Microglial Signaling Pathway in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Vitamin D Signaling Pathway in Neurodegeneration

rankings

nlrc5-protein

Infectious Triggers in Alzheimer's Disease