cell_type

T Cell

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about T Cell: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2339Connections

2Hypotheses

17Analyses

50Outgoing

50Incoming

Summary

T Cell is a cell type relevant to neurodegeneration research. Key relationships include: expressed in. Connected to 268 entities in the SciDEX knowledge graph.

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🧫 Cell Type Info

Cell Type	T Cell
Related Genes	PKD2, NOTCH, CXCR4, CD44, AIF, C9ORF72
Linked Hypotheses	194 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| T_Cell["T Cell"]
    HSPG2["HSPG2"] -->|"expressed in"| T_Cell["T Cell"]
    CANCER["CANCER"] -->|"expressed in"| T_Cell["T Cell"]
    TCR["TCR"] -->|"expressed in"| T_Cell["T Cell"]
    style T_Cell fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (132)

Target	Relation	Type	Str
Lewy Body Dementia	involved_in	disease	0.90
Dopaminergic Neuron	interacts_with	cell_type	0.85
Brain Homing	involved_in	process	0.85
Amyotrophic Lateral Sclerosis	involved_in	disease	0.80
T CELLS	activates	concept	0.50
B CELLS	activates	concept	0.50
Prostate Cancer	activates	disease	0.50
CELL PROLIFERATION	activates	concept	0.50
T CELLS	regulates	concept	0.50
T CELLS	inhibits	concept	0.50
T CELLS	expressed_in	concept	0.50
T CELLS	associated_with	concept	0.50
T CELLS	interacts_with	concept	0.50
VIRAL INFECTIONS	activates	concept	0.50
CYTOKINE	inhibits	concept	0.50
Immunotherapy	associated_with	process	0.50
CELL DEATH	activates	concept	0.50
Immune Checkpoint	activates	pathway	0.50
NEURONS	associated_with	concept	0.50
DOPAMINERGIC	associated_with	concept	0.50
DOPAMINERGIC NEURONS	associated_with	concept	0.50
B Cell	activates	cell_type	0.50
Immunotherapy	activates	process	0.50
disease	regulates	disease	0.50
BRAIN INFLAMMATION	regulates	concept	0.50
PARKINSON'S	regulates	concept	0.50
disease	associated_with	disease	0.50
PARKINSON'S	associated_with	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
SYNUCLEIN	interacts_with	concept	0.50
α-SYNUCLEIN	interacts_with	concept	0.50
SYNUCLEIN	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
disease	interacts_with	disease	0.50
PARKINSON'S	interacts_with	concept	0.50
Macrophage	regulates	cell_type	0.50
Epithelial Cell	regulates	cell_type	0.50
MACROPHAGES	regulates	concept	0.50
Macrophage	activates	cell_type	0.50
disease	activates	disease	0.50
Car-T	associated_with	pathway	0.50
Spinal Cord	activates	cell_type	0.50
Epithelial-Mesenchymal Transition	inhibits	process	0.50
METFORMIN	inhibits	concept	0.50
PD-L1	activates	concept	0.50
CELL PROLIFERATION	causes	concept	0.50
IL-1	activates	concept	0.50
DEMYELINATION	interacts_with	concept	0.50
NUCLEUS	activates	concept	0.50

Incoming (2207)

Source	Relation	Type	Str
Autophagy	modulates	process	0.80
Senescence-Associated Secretory Phenotype	expressed_in	phenotype	0.80
TAU	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
AGING	regulates	gene	0.60
E2F2	regulates	gene	0.60
E2F1	regulates	gene	0.60
DNA	associated_with	gene	0.60
E2F3	regulates	gene	0.60
E2F8	regulates	gene	0.60
E2F7	regulates	gene	0.60
CD8	regulates	gene	0.60
HSPG2	regulates	gene	0.60
COMPLEMENT	associated_with	gene	0.60
LOXL2	regulates	gene	0.60
HSP70	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
DNA	inhibits	gene	0.60
RNA	inhibits	gene	0.60
PARP1	inhibits	gene	0.60
DOT1L	associated_with	gene	0.60
RNA	activates	gene	0.60
PARP1	activates	gene	0.60
ABCB1	activates	gene	0.60
PLCG2	activates	gene	0.60
DNA	activates	gene	0.60
PRMT1	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
PRMT5	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
BATF3	activates	gene	0.60
TET2	activates	gene	0.60
PKD2	expressed_in	gene	0.60
TOMM20	regulates	gene	0.60
DRP1	regulates	gene	0.60
MAX	regulates	gene	0.60
HFE	regulates	gene	0.60
JUN	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
TFR1	causes	gene	0.60
FERROPTOSIS	activates	gene	0.60
TFR1	biomarker_for	gene	0.60
FERROPTOSIS	regulates	gene	0.60
CLOCK	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
NRF1	therapeutic_target	gene	0.60
SIRT1	activates	gene	0.60
DNM1L	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Senescent Cell ASM-Complement Cascade Intervention	0.552	neurodegeneration	Lipid raft composition changes in synapt
Senescent Cell Mitochondrial DNA Release	0.545	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (17)

Scientific analyses that reference this entity

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514

Which neural cell types exhibit the most pronounced gene expression alterations

neurodegeneration | 2026-04-11 | 0 hypotheses

Can metabolic interventions truly reverse established cellular senescence or onl

cell biology | 2026-04-08 | 0 hypotheses

How do host cell factors influence the conformation and propagation properties o

neurodegeneration | 2026-04-08 | 0 hypotheses

How do protein-protein interactions determine subcellular localization and funct

synaptic biology | 2026-04-08 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757]	["Bi D", "Yang X", "Wang Y", "Yong J", "	Frontiers in immunology	2026	0
Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577]	["Zhou R", "Lin X", "Liao Z", "Lin J", "	Ageing research reviews	2026	0
Role of NEIL1 in genome maintenance. [PMID:40010204]	["McCullough A", "Minko I", "Luzadder M"	DNA repair	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808]	["Lai P", "Liu L", "Bancaro N", "Troiani	Immunity	2025	0
Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559]	["Akgun Y"]	Ageing research reviews	2025	0
Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226]	["Daubermann C", "Herhaus B", "Neuberger	Molecular biology reports	2025	0
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587]	["Song Z", "Xie X", "Chen Y", "Zhang B",	Immunity	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014]	Chestnykh D, Mühle C, Schumacher F, Kali	Mol Psychiatry	2025	0
Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and P [PMID:40166037]	Cruchaga C, Heo G, Thomas A, Wang E, Oh	Res Sq	2025	0
Reduction of sphingomyelinase activity associated with progranulin deficiency an [PMID:40633679]	Boyle NR, Fox SN, Tadepalli AS, Seyfried	Neurobiol Dis	2025	0
Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604]	["Orlikova-Boyer B", "Lorant A", "Gajula	Biomarker research	2024	0
Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919]	["Li X", "Liu Y", "Ke J", "Wang Z", "Han	Advanced materials (Deerfield	2024	0
The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400]	Zhang Y, Zou M, Wu H, Zhu J, Jin T	Neurobiology of disease	2024	0
mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044]	["Li Y", "Cui J", "Liu L", "Hambright W"	Cell death & disease	2024	0
Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958]	["Byrns C", "Perlegos A", "Miller K", "J	Nature	2024	0
Acid sphingomyelinase as a pathological and therapeutic target in neurological d [PMID:38337058]	Choi BJ, Park MH, Jin HK, Bae JS	Exp Mol Med	2024	0
EDIL3/Del-1 prevents aortic dissection through enhancing internalization and deg [PMID:38873925]	Yin Z, Zhang J, Zhao M, Liu J, Xu Y et a	Autophagy	2024	0

T Cell

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

neuroinflammation

Pathway Diagram

Outgoing (132)

Incoming (2207)

Targeting Hypotheses (2)

Mentioning Analyses (17)

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

Which neural cell types exhibit the most pronounced gene expression alterations

Can metabolic interventions truly reverse established cellular senescence or onl

How do host cell factors influence the conformation and propagation properties o

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive microglial senescence and the transition to dyst

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Related Papers (20)

T Cell

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

neuroinflammation

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration

Autophagy Mechanisms

Oligodendrocytes

Vitamin D Signaling Pathway in Neurodegeneration

rankings

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Spinal Cord Dorsal Horn Neurons

nlrc5-protein

dimethyl-fumarate-nrf2-ad-nct06850597

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

LRRK2 Pathway in Parkinson's Disease

CREB Signaling in Neurodegeneration

Amyloid Cascade Pathway

vitamin-d-therapy-neurodegeneration

Pathway Diagram

Outgoing (132)

Incoming (2207)

Targeting Hypotheses (2)

Mentioning Analyses (17)

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

Which neural cell types exhibit the most pronounced gene expression alterations

Can metabolic interventions truly reverse established cellular senescence or onl

How do host cell factors influence the conformation and propagation properties o

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive microglial senescence and the transition to dyst

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Related Papers (20)