Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RAB12 |
| Full Name | RAB12, Member RAS Oncogene Family |
| Chromosome | 18p11.22 |
| Function | RAB12 encodes a member of the RAB family of small GTPases, which are key regulators of intracellular vesicle trafficking. |
| Primary Expression | the substantia nigra, and dysregulated RAB12 function may contribute to: |
| Molecular Weight | 24 kDa |
| Pathways | mTOR, mtor |
| UniProt ID | Q96CM8 |
| NCBI Gene ID | 157556 |
| Ensembl ID | ENSG00000139433 |
| GeneCards | RAB12 |
| Human Protein Atlas | RAB12 |
| Strategy | Approach |
| [Autophagy](/entities/autophagy) enhancement | Small molecules to enhance RAB12-mediated autophagy |
| Gene therapy | AAV-mediated RAB12 overexpression |
| Associated Diseases | neurodegeneration |
| Interactions | LRRK2, RAB10, JIP4 |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB12["RAB12"]
ALS["ALS"]
RAB12 -->|"regulates"| ALS
Parkinson["Parkinson"]
RAB12 -->|"phosphorylates"| Parkinson
LRRK2["LRRK2"]
LRRK2 -->|"interacts_with"| RAB12
RAB10["RAB10"]
RAB10 -->|"interacts_with"| RAB12
Astrocyte["Astrocyte"]
RAB12 -->|"expressed_in"| Astrocyte
neurodegeneration["neurodegeneration"]
RAB12 -->|"implicated_in"| neurodegeneration
style RAB12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | regulates | disease | 0.65 |
| Parkinson | phosphorylates | disease | 0.65 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| astrocytes | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||