gene

RAB1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

10Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for RAB1A - Rab GTPase regulating ER-Golgi transport, alpha-synuclein trafficking, and mitochondrial dynamics in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	RAB1A
Full Name	Ras-Related Protein Rab-1A
Aliases	Page for RAB1A
Chromosome	2p24.1
Function	is a member of the Rab GTPase family that regulates vesicle trafficking between the endoplasmic reticulum (ER) and Golgi apparatus [1](https://pubmed.
Subcellular Localization	specificity</td>
Molecular Weight	22 kDa
Amino Acids	205 aa
UniProt ID	P62820
NCBI Gene ID	5876
Ensembl ID	ENSG00000100739
GeneCards	RAB1A
Human Protein Atlas	RAB1A
Associated Diseases	neurodegeneration
Interactions	AUTOPHAGY, C9ORF72, ULK1
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB1A — AlphaFold P62820 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAB1A — Ras-Related Protein Rab-1A

gene · 1122 words

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Pathway Diagram

graph TD
    RAB1A["<b>RAB1A</b>"]
    Als{"Als"}
    RAB1A -->|"regulates"| Als
    Dementia{"Dementia"}
    RAB1A -->|"regulates"| Dementia
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    RAB1A -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    P62["P62"]
    RAB1A -->|"regulates"| P62
    ULK1["ULK1"]
    RAB1A -->|"interacts with"| ULK1
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    RAB1A -->|"regulates"| AMYOTROPHIC_LATERAL_SCLEROSIS
    AUTOPHAGY["AUTOPHAGY"]
    RAB1A -->|"interacts with"| AUTOPHAGY
    C9ORF72["C9ORF72"]
    RAB1A -->|"interacts with"| C9ORF72
    ALS["ALS"]
    RAB1A -->|"regulates"| ALS
    Autophagy(["Autophagy"])
    RAB1A -->|"interacts with"| Autophagy
    neurodegeneration["neurodegeneration"]
    RAB1A -->|"implicated in"| neurodegeneration
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"regulates"| RAB1A
    style RAB1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Dementia	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ALS	regulates	gene	0.60
P62	regulates	gene	0.60
Autophagy	interacts_with	pathway	0.60
ULK1	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
UBIQUITIN	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity