gene

RAB4B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections
0Hypotheses
0Analyses
16Outgoing
8Incoming

Summary

RAB4B - Small GTPase involved in synaptic vesicle recycling, endocytic trafficking, and neurodegenerative disease mechanisms

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🧬 Gene Info
Gene SymbolRAB4B
Full NameRAB4B, Member RAS Oncogene Family
Chromosome15q21.2
FunctionSynaptic vesicles fuse with presynaptic membrane to release neurotransmitters
Primary ExpressionBrain (high), heart, lung, testis
Amino Acids219 aa
UniProt ID[Q9NPF7](https://www.uniprot.org/uniprot/Q9NPF7)
Ensembl IDENSG00000167842
GeneCardsRAB4B
Human Protein AtlasRAB4B
Associated DiseasesALS
KG Connections24 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

RAB4B Gene

gene · 2951 words

synaptic-vesicle-trafficking-pathway

mechanism · 2944 words

rab3c Gene

gene · 1302 words

RAB4A Gene

gene · 873 words

RAB11B - RAB11B

gene · 522 words

Genes

index · 271 words

Pathway Diagram

graph TD
    RAB4B["<b>RAB4B</b>"]
    Als{"Als"}
    RAB4B -->|"associated with"| Als
    ALS{"ALS"}
    RAB4B -->|"associated with"| ALS
    RAB27B["RAB27B"]
    RAB4B -->|"associated with"| RAB27B
    RAB3C["RAB3C"]
    RAB4B -->|"associated with"| RAB3C
    RAB5["RAB5"]
    RAB4B -->|"associated with"| RAB5
    RAB3B["RAB3B"]
    RAB4B -->|"associated with"| RAB3B
    RAB5A["RAB5A"]
    RAB4B -->|"associated with"| RAB5A
    RAB11B["RAB11B"]
    RAB4B -->|"associated with"| RAB11B
    RAB10["RAB10"]
    RAB4B -->|"associated with"| RAB10
    RAB3A["RAB3A"]
    RAB4B -->|"associated with"| RAB3A
    Exocytosis(["Exocytosis"])
    RAB4B -->|"associated with"| Exocytosis
    Synaptic_Vesicle(["Synaptic Vesicle"])
    RAB4B -->|"associated with"| Synaptic_Vesicle
    RAB10 -->|"associated with"| RAB4B
    RAB11B -->|"associated with"| RAB4B
    RAB27B -->|"associated with"| RAB4B
    RAB5A -->|"associated with"| RAB4B
    RAB3B -->|"associated with"| RAB4B
    RAB3A -->|"associated with"| RAB4B
    RAB5 -->|"associated with"| RAB4B
    RAB3C -->|"associated with"| RAB4B
    AND["AND"]
    AND -->|"associated with"| RAB4B
    style RAB4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

TargetRelationTypeStr
Alsassociated_withdisease0.65
ALSassociated_withdisease0.65
Alstransportsdisease0.65
RAB27Bassociated_withgene0.60
RAB3Cassociated_withgene0.60

Incoming (8)

SourceRelationTypeStr
RAB10associated_withgene0.60
RAB11Bassociated_withgene0.60
RAB27Bassociated_withgene0.60
RAB5Aassociated_withgene0.60
RAB3Bassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found