Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB4B - Small GTPase involved in synaptic vesicle recycling, endocytic trafficking, and neurodegenerative disease mechanisms
| Gene Symbol | RAB4B |
| Full Name | RAB4B, Member RAS Oncogene Family |
| Chromosome | 15q21.2 |
| Function | Synaptic vesicles fuse with presynaptic membrane to release neurotransmitters |
| Primary Expression | Brain (high), heart, lung, testis |
| Amino Acids | 219 aa |
| UniProt ID | [Q9NPF7](https://www.uniprot.org/uniprot/Q9NPF7) |
| Ensembl ID | ENSG00000167842 |
| GeneCards | RAB4B |
| Human Protein Atlas | RAB4B |
| Associated Diseases | ALS |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB4B["<b>RAB4B</b>"]
Als{"Als"}
RAB4B -->|"associated with"| Als
ALS{"ALS"}
RAB4B -->|"associated with"| ALS
RAB27B["RAB27B"]
RAB4B -->|"associated with"| RAB27B
RAB3C["RAB3C"]
RAB4B -->|"associated with"| RAB3C
RAB5["RAB5"]
RAB4B -->|"associated with"| RAB5
RAB3B["RAB3B"]
RAB4B -->|"associated with"| RAB3B
RAB5A["RAB5A"]
RAB4B -->|"associated with"| RAB5A
RAB11B["RAB11B"]
RAB4B -->|"associated with"| RAB11B
RAB10["RAB10"]
RAB4B -->|"associated with"| RAB10
RAB3A["RAB3A"]
RAB4B -->|"associated with"| RAB3A
Exocytosis(["Exocytosis"])
RAB4B -->|"associated with"| Exocytosis
Synaptic_Vesicle(["Synaptic Vesicle"])
RAB4B -->|"associated with"| Synaptic_Vesicle
RAB10 -->|"associated with"| RAB4B
RAB11B -->|"associated with"| RAB4B
RAB27B -->|"associated with"| RAB4B
RAB5A -->|"associated with"| RAB4B
RAB3B -->|"associated with"| RAB4B
RAB3A -->|"associated with"| RAB4B
RAB5 -->|"associated with"| RAB4B
RAB3C -->|"associated with"| RAB4B
AND["AND"]
AND -->|"associated with"| RAB4B
style RAB4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Als | transports | disease | 0.65 |
| RAB27B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| Synaptic Vesicle | associated_with | pathway | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| Fus | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||