Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB3B is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, contributes to. Associated with ALS, Als, Autoimmune. Connected to 32 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB3B |
| Chromosome | 1p31.1 |
| Function | The RAB3B gene encodes a 219-amino acid protein that functions as a molecular switch in vesicle trafficking: |
| Primary Expression | neuronal and neuroendocrine cells, where they control synaptic vesicle dynamics essential for neurotransmission |
| Amino Acids | 219 aa |
| Ensembl ID | ENSG00000169258 |
| GeneCards | RAB3B |
| Human Protein Atlas | RAB3B |
| Associated Diseases | ALS, Alzheimer, dementia, frontotemporal, neurodegeneration |
| Interactions | GFAP, CHRNA6, CALB2 |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB3B["<b>RAB3B</b>"]
Als{"Als"}
RAB3B -->|"associated with"| Als
Schizophrenia{"Schizophrenia"}
RAB3B -->|"inhibits"| Schizophrenia
Cancer{"Cancer"}
RAB3B -->|"contributes to"| Cancer
Depression{"Depression"}
RAB3B -->|"inhibits"| Depression
Ms{"Ms"}
RAB3B -->|"inhibits"| Ms
Autoimmune{"Autoimmune"}
RAB3B -->|"contributes to"| Autoimmune
ALS{"ALS"}
RAB3B -->|"associated with"| ALS
RAB5A["RAB5A"]
RAB3B -->|"associated with"| RAB5A
RAB11B["RAB11B"]
RAB3B -->|"associated with"| RAB11B
RAB10["RAB10"]
RAB3B -->|"associated with"| RAB10
RAB3A["RAB3A"]
RAB3B -->|"associated with"| RAB3A
Exocytosis(["Exocytosis"])
RAB3B -->|"associated with"| Exocytosis
RAB4B["RAB4B"]
RAB4B -->|"associated with"| RAB3B
RAB27B["RAB27B"]
RAB27B -->|"associated with"| RAB3B
RAB3C["RAB3C"]
RAB3C -->|"associated with"| RAB3B
RAB5["RAB5"]
RAB5 -->|"associated with"| RAB3B
RAB3A -->|"associated with"| RAB3B
RAB10 -->|"associated with"| RAB3B
RAB11B -->|"associated with"| RAB3B
GFAP["GFAP"]
GFAP -->|"inhibits"| RAB3B
CHRNA6["CHRNA6"]
CHRNA6 -->|"inhibits"| RAB3B
CANCER["CANCER"]
CANCER -->|"contributes to"| RAB3B
CALB2["CALB2"]
CALB2 -->|"inhibits"| RAB3B
RAB5A -->|"associated with"| RAB3B
style RAB3B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Synaptic Plasticity | involved_in | process | 0.90 |
| Synaptic plasticity | involved_in | process | 0.80 |
| Als | associated_with | disease | 0.65 |
| Schizophrenia | inhibits | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| Depression | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Autoimmune | contributes_to | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Als | transports | disease | 0.65 |
| RAB5A | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| RAB4B | associated_with | gene | 0.60 |
| Synaptic Vesicle | associated_with | pathway | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| frontotemporal | associated_with | disease | 0.60 |
| SLC1A2 | implicated_in | gene | 0.60 |
| SYNPO | implicated_in | gene | 0.60 |
| TUBB2B | implicated_in | gene | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| Epigenetic | inhibits | pathway | 0.60 |
| Notch | contributes_to | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| Fus | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| dementia | associated_with | disease | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| RNA | implicated_in | gene | 0.60 |
| SLC1A2 | co_expressed_with | gene | 0.50 |
| SYNPO | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RAB4B | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| GFAP | inhibits | gene | 0.60 |
| CHRNA6 | inhibits | gene | 0.60 |
| CALB2 | inhibits | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| CADM1 | implicated_in | gene | 0.60 |
| COMT | implicated_in | gene | 0.60 |
| ITPKA | implicated_in | gene | 0.60 |
| LRFN1 | implicated_in | gene | 0.60 |
| NCAN | implicated_in | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| FTLD | implicated_in | gene | 0.60 |
| LRFN1 | co_expressed_with | gene | 0.50 |
| MAPT | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||