gene

RAB3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections
0Hypotheses
0Analyses
36Outgoing
20Incoming

Summary

RAB3B is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, contributes to. Associated with ALS, Als, Autoimmune. Connected to 32 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAB3B
Chromosome1p31.1
FunctionThe RAB3B gene encodes a 219-amino acid protein that functions as a molecular switch in vesicle trafficking:
Primary Expressionneuronal and neuroendocrine cells, where they control synaptic vesicle dynamics essential for neurotransmission
Amino Acids219 aa
Ensembl IDENSG00000169258
GeneCardsRAB3B
Human Protein AtlasRAB3B
Associated DiseasesALS, Alzheimer, dementia, frontotemporal, neurodegeneration
InteractionsGFAP, CHRNA6, CALB2
KG Connections56 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAB3B Gene

gene · 891 words

RAB4B Gene

gene · 2951 words

synaptic-vesicle-trafficking-pathway

mechanism · 2944 words

rab3b-protein

protein · 2516 words

TUBB2B — Tubulin Beta 2B Class IIb

gene · 2334 words

LRFN1 — Leucine Rich Repeat and Fibronectin Type III Domain Containing 1

gene · 2282 words

Pathway Diagram

graph TD
    RAB3B["<b>RAB3B</b>"]
    Als{"Als"}
    RAB3B -->|"associated with"| Als
    Schizophrenia{"Schizophrenia"}
    RAB3B -->|"inhibits"| Schizophrenia
    Cancer{"Cancer"}
    RAB3B -->|"contributes to"| Cancer
    Depression{"Depression"}
    RAB3B -->|"inhibits"| Depression
    Ms{"Ms"}
    RAB3B -->|"inhibits"| Ms
    Autoimmune{"Autoimmune"}
    RAB3B -->|"contributes to"| Autoimmune
    ALS{"ALS"}
    RAB3B -->|"associated with"| ALS
    RAB5A["RAB5A"]
    RAB3B -->|"associated with"| RAB5A
    RAB11B["RAB11B"]
    RAB3B -->|"associated with"| RAB11B
    RAB10["RAB10"]
    RAB3B -->|"associated with"| RAB10
    RAB3A["RAB3A"]
    RAB3B -->|"associated with"| RAB3A
    Exocytosis(["Exocytosis"])
    RAB3B -->|"associated with"| Exocytosis
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB3B
    RAB27B["RAB27B"]
    RAB27B -->|"associated with"| RAB3B
    RAB3C["RAB3C"]
    RAB3C -->|"associated with"| RAB3B
    RAB5["RAB5"]
    RAB5 -->|"associated with"| RAB3B
    RAB3A -->|"associated with"| RAB3B
    RAB10 -->|"associated with"| RAB3B
    RAB11B -->|"associated with"| RAB3B
    GFAP["GFAP"]
    GFAP -->|"inhibits"| RAB3B
    CHRNA6["CHRNA6"]
    CHRNA6 -->|"inhibits"| RAB3B
    CANCER["CANCER"]
    CANCER -->|"contributes to"| RAB3B
    CALB2["CALB2"]
    CALB2 -->|"inhibits"| RAB3B
    RAB5A -->|"associated with"| RAB3B
    style RAB3B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

TargetRelationTypeStr
Synaptic Plasticityinvolved_inprocess0.90
Synaptic plasticityinvolved_inprocess0.80
Alsassociated_withdisease0.65
Schizophreniainhibitsdisease0.65
Cancercontributes_todisease0.65

Incoming (20)

SourceRelationTypeStr
RAB4Bassociated_withgene0.60
RAB27Bassociated_withgene0.60
RAB3Cassociated_withgene0.60
RAB5associated_withgene0.60
RAB3Aassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found