Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB3C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB3C is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with ALS, Als. Connected to 21 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB3C |
| Chromosome | 22 |
| Function | The RAB3C (RAB3C, Member RAS Oncogene Family) gene encodes a member of the Rab GTPase family, which is part of the Ras superfamily of small GTPases |
| Primary Expression | neuronal and neuroendocrine tissues, where it plays essential roles in regulated secretion, synaptic vesicle trafficking, and neurotransmitter release |
| Molecular Weight | 30 kDa |
| Exons | Multiple exons spanning approximately 20 kb |
| Pathways | Glycolysis |
| Ensembl ID | ENSG00000172985 |
| GeneCards | RAB3C |
| Human Protein Atlas | RAB3C |
| Location | 22q12.3 |
| Transcript | Protein-coding gene with multiple splice variants |
| Promoter | Contains neuron-specific regulatory elements |
| GTP-binding domain (G-domain) | Consists of five highly conserved G motifs (GxxxxGKST, DxxG, NKXD, T/SAK, WDTAGLE) that mediate nucleotide binding and hydrolysis |
| Switch I region | Undergoes dramatic conformational change upon GTP/GDP exchange, mediates effector protein binding |
| Associated Diseases | ALS |
| Interactions | Stat3, Il-6, ATP |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB3C["<b>RAB3C</b>"]
Als{"Als"}
RAB3C -->|"associated with"| Als
ALS{"ALS"}
RAB3C -->|"associated with"| ALS
RAB5["RAB5"]
RAB3C -->|"associated with"| RAB5
RAB3B["RAB3B"]
RAB3C -->|"associated with"| RAB3B
RAB5A["RAB5A"]
RAB3C -->|"associated with"| RAB5A
RAB11B["RAB11B"]
RAB3C -->|"associated with"| RAB11B
RAB10["RAB10"]
RAB3C -->|"associated with"| RAB10
RAB3A["RAB3A"]
RAB3C -->|"associated with"| RAB3A
Exocytosis(["Exocytosis"])
RAB3C -->|"associated with"| Exocytosis
RAB27B["RAB27B"]
RAB3C -->|"associated with"| RAB27B
RAB4B["RAB4B"]
RAB3C -->|"associated with"| RAB4B
Synaptic_Vesicle(["Synaptic Vesicle"])
RAB3C -->|"associated with"| Synaptic_Vesicle
RAB4B -->|"associated with"| RAB3C
RAB27B -->|"associated with"| RAB3C
RAB3A -->|"associated with"| RAB3C
RAB3B -->|"associated with"| RAB3C
RAB10 -->|"associated with"| RAB3C
RAB11B -->|"associated with"| RAB3C
RAB5A -->|"associated with"| RAB3C
RAB5 -->|"associated with"| RAB3C
AND["AND"]
AND -->|"associated with"| RAB3C
style RAB3C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Als | transports | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| RAB5 | associated_with | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| RAB4B | associated_with | gene | 0.60 |
| Synaptic Vesicle | associated_with | pathway | 0.60 |
| Stat3 | activates | protein | 0.60 |
| Il-6 | activates | protein | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| Fus | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| Glycolysis | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||