protein

RAB27B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB27B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections
0Hypotheses
0Analyses
47Outgoing
24Incoming
0Experiments

Summary

RAB27B is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, causes. Associated with ALS, Als, Ms. Connected to 31 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolRAB27B
Full NameRAB27B, Member RAS Oncogene Family
Chromosome18q21.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight24.8 kDa
PathwaysMultivesicular Endosome Docking, Synaptic Vesicle Exocytosis
UniProt IDQ9UQ26
NCBI Gene ID26789
Ensembl IDENSG00000167510
OMIM605342
GeneCardsRAB27B
Human Protein AtlasRAB27B
Protein ClassSmall GTPase (Rab family)
SpeciesHuman
Associated DiseasesALS
InteractionsRAB3A, RNA, ENDOSOMES, RAB27A, EXPH5, EXOSOMES
KG Connections71 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RAB27B — AlphaFold Q9UQ26 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

RAB27B Gene

gene · 748 words

Parkinson's Disease

disease · 8807 words

Exosome Biogenesis in Neurodegeneration

mechanism · 3104 words

RAB4B Gene

gene · 2951 words

synaptic-vesicle-trafficking-pathway

mechanism · 2944 words

Endolysosomal Pathway in Alzheimer's Disease

mechanism · 2036 words

Pathway Diagram

graph TD
    RAB27B["<b>RAB27B</b>"]
    Ms{"Ms"}
    RAB27B -->|"activates"| Ms
    Als{"Als"}
    RAB27B -->|"inhibits"| Als
    RAB27B -->|"associated with"| Als
    ALS{"ALS"}
    RAB27B -->|"inhibits"| ALS
    RAB27B -->|"associated with"| ALS
    RAB3C["RAB3C"]
    RAB27B -->|"associated with"| RAB3C
    RAB5["RAB5"]
    RAB27B -->|"associated with"| RAB5
    RAB3B["RAB3B"]
    RAB27B -->|"associated with"| RAB3B
    RAB5A["RAB5A"]
    RAB27B -->|"associated with"| RAB5A
    RAB11B["RAB11B"]
    RAB27B -->|"associated with"| RAB11B
    RAB10["RAB10"]
    RAB27B -->|"associated with"| RAB10
    RAB3A["RAB3A"]
    RAB27B -->|"activates"| RAB3A
    RAB27A["RAB27A"]
    RAB27A -->|"regulates"| RAB27B
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB27B
    RAB3A -->|"activates"| RAB27B
    RAB3B -->|"associated with"| RAB27B
    RAB10 -->|"associated with"| RAB27B
    RAB11B -->|"associated with"| RAB27B
    RAB3C -->|"associated with"| RAB27B
    RAB5A -->|"associated with"| RAB27B
    RAB5 -->|"associated with"| RAB27B
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"activates"| RAB27B
    EXOSOMES["EXOSOMES"]
    EXOSOMES -->|"activates"| RAB27B
    AND["AND"]
    AND -->|"regulates"| RAB27B
    style RAB27B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

TargetRelationTypeStr
Synaptic Vesicle Exocytosisinvolved_inprocess0.95
Exosome Secretionregulatesprocess0.95
Exosome Secretionpromotesprocess0.95
multivesicular endosome dockingregulatesprocess0.90
Multivesicular Endosome Dockinginvolved_inprocess0.90

Incoming (24)

SourceRelationTypeStr
RAB3Ainteracts_withprotein0.85
Synaptic Vesicle Recyclinginvolved_inprocess0.80
RAB27Ainteracts_withprotein0.80
RAB27Aassociated_withentity0.60
RAB27Aupregulatesentity0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found