Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAD54: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAD54 (RAD54 homolog) is a DNA-dependent ATPase involved in homologous recombination and DNA repair. It plays critical roles in DNA double-strand break repair, transcription regulation, and has been implicated in cancer and neurological disorders.
| Gene Symbol | RAD54 |
| Aliases | RAD54 homolog |
| Chromosome | 1p36.11 |
| Protein Family | SWI2/SNF2 family |
| Function | DNA bending and protein-protein interactions |
| Molecular Weight | 83 kDa |
| Amino Acids | 754 aa |
| Exons | 21 |
| Pathways | ubiquitin-proteasome |
| NCBI Gene ID | 8438 |
| GeneCards | RAD54 |
| Human Protein Atlas | RAD54 |
| RAD51 | Direct binding |
| RAD51B | Complex formation |
| RAD51C | Complex formation |
| Associated Diseases | neurodegeneration |
| Interactions | VCP, RAD51, ATR, ATM, DNA, MCM8 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
RAD54["<b>RAD54</b>"]
VCP["VCP"]
RAD54 -->|"activates"| VCP
RAD51["RAD51"]
RAD54 -->|"activates"| RAD51
ATR["ATR"]
RAD54 -->|"activates"| ATR
ATM["ATM"]
RAD54 -->|"activates"| ATM
DNA["DNA"]
RAD54 -->|"activates"| DNA
MCM8["MCM8"]
RAD54 -->|"activates"| MCM8
neurodegeneration["neurodegeneration"]
RAD54 -->|"implicated in"| neurodegeneration
ATM -->|"activates"| RAD54
ATR -->|"activates"| RAD54
RAD51 -->|"activates"| RAD54
DNA -->|"activates"| RAD54
VCP -->|"activates"| RAD54
AND["AND"]
AND -->|"activates"| RAD54
style RAD54 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| VCP | activates | gene | 0.60 |
| RAD51 | activates | gene | 0.60 |
| ATR | activates | gene | 0.60 |
| ATM | activates | gene | 0.60 |
| DNASE2 | expressed_in | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| MCM8 | activates | gene | 0.60 |
| RFWD3 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| T Cell | expressed_in | cell_type | 0.60 |
| AND | associated_with | gene | 0.60 |
| Cell Cycle | associated_with | pathway | 0.60 |
| Dna Repair | expressed_in | pathway | 0.60 |
| Ubiquitin | activates | protein | 0.60 |
| App | expressed_in | protein | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| VCP | co_expressed_with | gene | 0.50 |
| CELL CYCLE | associated_with | cell_type | 0.50 |
| DNA DAMAGE | associated_with | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||