gene 511 words KG: RAD51 2026-03-24
kind:genesection:genesstate:published
Contents

RAD51

🧬 Gene Info
Gene SymbolRAD51
Full NameRAD51 Recombinase
Chromosome15q15.1
FunctionRAD51 is a recombinase protein essential for homologous recombination (HR) repair of double-strand DNA breaks.
Primary Expressionall brain regions, with particularly high expression in dopaminergic neurons of the substantia nigra, motor cortex, and hippo
Molecular Weight37 kDa
Amino Acids339 aa
PathwaysHomologous Recombination
UniProt IDP43251
NCBI Gene ID5888
Ensembl IDENSG00000102009
OMIM179520
GeneCardsRAD51
Human Protein AtlasRAD51
Associated Diseasesneurodegeneration
InteractionsATR, ATM, RAD54, VCP, UBIQUITIN, DNA
KG Connections68 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Early Proteasome Restoration Therapy
Score: 0.50
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48
Axonal RNA Transport Reconstitution
Score: 0.45
Extracellular Matrix Stiffness Modulation
Score: 0.43

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Packard Center for ALS Research
institution · KG edge: activates
RAD54 Gene
gene · KG edge: activates
PTEN Gene
gene · KG edge: regulates
PALB2 Gene
gene · KG edge: regulates
NF1 — Neurofibromin 1
gene · KG edge: regulates

Knowledge Graph (12 edges)

RAD51 activates ATR
RAD51 activates ATM
RAD51 activates RAD54
RAD51 activates VCP
RAD51 regulates NF1
RAD51 regulates BRCA2
RAD51 degrades RAD54
RAD51 involved_in Homologous Recombination
RAD51 interacts_with UBIQUITIN
RAD51 co_expressed_with RAD54