gene 976 words KG: NEK1 2026-03-24
kind:genesection:genesstate:published
Contents

NEK1 — NIMA Related Kinase 1

🧬 Gene Info
Gene SymbolNEK1
Full NameNIMA Related Kinase 1
Chromosome4q33
Protein TypeSerine/Threonine Kinase
FunctionNEK1 is a multifunctional kinase with roles spanning several critical cellular processes.
Primary ExpressionMotor cortex, Spinal cord, Widespread
Molecular Weight145 kDa
UniProt IDQ96PY6
NCBI Gene ID4750
Ensembl IDENSG00000137601
OMIM604588
GeneCardsNEK1
Human Protein AtlasNEK1
Symbol [@white2007] NEK1 [@fang2015] [@rifai2025] [@sagu2024] Full Name [@helal2025] NIMA Related Kinase 1 Chromosome4q33
Associated DiseasesALS, APOPTOSIS, Amyotrophic Lateral Sclerosis, Ms
InteractionsStat3, TBK1, RIPK1, App, STAT3, HDAC8
KG Connections108 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

PARP1 Inhibition Therapy
Score: 0.58
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (9)

Hedgehog Signaling in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
HDAC8 Gene
gene · KG edge: activates
CHCHD10 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Co
gene · KG edge: associated_with
C21orf2 — Chromosome 21 Open Reading Frame 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NEK1 therapeutic_target SOD1
NEK1 associated_with TBK1
NEK1 contributes_to VCP
NEK1 contributes_to C21ORF2
NEK1 associated_with CHCHD10
NEK1 associated_with C21ORF2
NEK1 inhibits Stat3
NEK1 causes SETX
NEK1 causes SOD1
NEK1 causes SQSTM1