concept

DNA DAMAGE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNA DAMAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

294Connections

1Hypotheses

0Analyses

46Outgoing

50Incoming

Summary

DNA DAMAGE is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA, CANCER. Connected to 86 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DNA DAMAGE
Key Genes/Proteins	Proteins
Related Diseases	COLORECTAL CANCER, Inflammatory Bowel Disease
Related Pathways	Dna Damage Response, Microrna
Linked Hypotheses	3 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DNA_DAMAGE["<b>DNA DAMAGE</b>"]
    DNA_DAMAGE -->|"causes"| Neuronal_Functions["Neuronal Functions"]
    DNA_DAMAGE -->|"risk_factor_for"| Neurodegeneration["Neurodegeneration"]
    DNA_DAMAGE -->|"contributes to"| Neuronal_Aging["Neuronal Aging"]
    DNA_DAMAGE -->|"modulates"| Chromatin_Topology["Chromatin Topology"]
    DNA_DAMAGE -->|"contributes to"| Follicular_Atresia["Follicular Atresia"]
    DNA_DAMAGE -->|"transports"| T_CELL["T CELL"]
    DNA_DAMAGE -->|"transports"| T_CELLS["T CELLS"]
    DNA_DAMAGE -->|"transports"| TUMOR["TUMOR"]
    DNA_DAMAGE -->|"interacts"| EGF["EGF"]
    DNA_DAMAGE -->|"interacts"| HMGB1["HMGB1"]
    DNA_DAMAGE -->|"activates"| JNK["JNK"]
    miR_139_5p_Mimic["miR-139-5p Mimic"] -->|"causes"| DNA_DAMAGE
    CSNK2A1["CSNK2A1"] -->|"regulates"| DNA_DAMAGE
    NOTCH1["NOTCH1"] -->|"regulates"| DNA_DAMAGE
    oxidative_stress["oxidative stress"] -->|"causes"| DNA_DAMAGE
    Oxidative_Stress["Oxidative Stress"] -->|"causes"| DNA_DAMAGE
    GSK2606414["GSK2606414"] -.protects against.-> DNA_DAMAGE
    TFEB["TFEB"] -->|"inhibits"| DNA_DAMAGE
    TDP_43_mislocalization["TDP-43 mislocalization"] -->|"activates"| DNA_DAMAGE
    CGAS["CGAS"] -->|"causes"| DNA_DAMAGE
    AUTOPHAGY["AUTOPHAGY"] -->|"transports"| DNA_DAMAGE
    CANCER["CANCER"] -->|"transports"| DNA_DAMAGE

Outgoing (78)

Target	Relation	Type	Str
Dna Damage Response	regulates	pathway	0.50
Tumor Microenvironment	activates	process	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50
RAPAMYCIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
PEROXISOME	activates	concept	0.50
CHRONIC INFLAMMATION	activates	concept	0.50
Proteins	associated_with	protein	0.50
Dna Damage Response	activates	pathway	0.50
MOTOR NEURON	activates	concept	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
BREAST CANCER	activates	disease	0.50
Microrna	regulates	pathway	0.50
Microrna	inhibits	pathway	0.50
GLIOSIS	activates	concept	0.50
DENDRITIC SPINE	inhibits	concept	0.50
Cellular Senescence	associated_with	cell_type	0.50
OLIGODENDROCYTES	activates	concept	0.50
IPSC	activates	concept	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
CYTOKINE	activates	concept	0.50
Cognitive Decline	associated_with	disease	0.50
Infection	associated_with	disease	0.50
Dna Damage Response	associated_with	pathway	0.50
STEM CELLS	activates	concept	0.50
HER2	activates	concept	0.50
PD-L1	activates	concept	0.50
Dysbiosis	inhibits	disease	0.50
Telomere	inhibits	pathway	0.50
Cellular Senescence	activates	cell_type	0.50
Dna Damage Response	interacts_with	pathway	0.50
GENE EXPRESSION	interacts_with	concept	0.50
Telomere	activates	pathway	0.50
GENE EXPRESSION	expressed_in	concept	0.50
Epithelial-Mesenchymal Transition	inhibits	process	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
CX43	inhibits	concept	0.50
Proteins	interacts_with	protein	0.50
FRONTAL	regulates	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
Dna Damage Response	inhibits	pathway	0.50

Incoming (216)

Source	Relation	Type	Str
Autophagy	activates	process	0.50
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
Stem Cell	activates	cell_type	0.50
LRRK2	activates	gene	0.50
Pi3K	activates	pathway	0.50
TFEB	activates	protein	0.50
EGFR	activates	gene	0.50
EIF2A	activates	protein	0.50
STING1	activates	protein	0.50
RICTOR	activates	gene	0.50
EIF2AK3	activates	gene	0.50
DDIT3	activates	gene	0.50
MLKL	activates	gene	0.50
OPTN	activates	gene	0.50
STAT3	activates	gene	0.50
DEPTOR	activates	gene	0.50
RIPK1	activates	gene	0.50
FIP200	activates	gene	0.50
GABA	activates	gene	0.50
ERN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
PPARG	activates	gene	0.50
GRB2	activates	gene	0.50
RPS6KB1	activates	gene	0.50
HSPA5	activates	gene	0.50
RHEB	activates	gene	0.50
PIK3C3	activates	gene	0.50
RPTOR	activates	gene	0.50
MAP1LC3A	activates	gene	0.50
TFE3	activates	gene	0.50
RB1CC1	activates	gene	0.50
MAPK14	activates	gene	0.50
HMGB1	activates	gene	0.50
MAVS	activates	gene	0.50
MLST8	activates	gene	0.50
NBR1	activates	gene	0.50
RIBOSOMAL PROTEIN S6	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
HSP70	activates	protein	0.50
ENDOPHILIN	activates	protein	0.50
P38 Mapk	activates	pathway	0.50
GABARAP	activates	protein	0.50
GRP78	activates	protein	0.50
VPS34	activates	protein	0.50
IFNG	activates	gene	0.50
MAPK	activates	gene	0.50
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
MTORC1	activates	concept	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.562	neurodegeneration	What upstream mechanisms trigger p53 act

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DNA DAMAGE

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

Alzheimer's Disease Mechanism Index

Therapeutics

NPM1 Gene

neuroinflammation

NRF2 Oxidative Stress Pathway

Frontotemporal Dementia (FTD)

Mitochondrial Dysfunction in Parkinson's Disease

Synucleinopathy Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

Mitophagy Pathway in Neurodegeneration

University of Heidelberg

Vascular Cognitive Impairment (VCI)