concept

DNA DAMAGE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNA DAMAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

311Connections

5Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

DNA DAMAGE is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA, CANCER. Connected to 86 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DNA DAMAGE
Key Genes/Proteins	ACTB, ALS4, amyotrophic lateral sclerosis, AQP1, ARNTL, ASXL1
Related Diseases	aging, Ataxia, ataxia-telangiectasia

Pathway Diagram

graph TD
    DNA_DAMAGE["DNA DAMAGE"]
    DNA_DAMAGE -->|"causes"| Neuronal_Functions["Neuronal Functions"]
    DNA_DAMAGE -->|"risk_factor_for"| Neurodegeneration["Neurodegeneration"]
    DNA_DAMAGE -->|"contributes to"| Neuronal_Aging["Neuronal Aging"]
    DNA_DAMAGE -->|"modulates"| Chromatin_Topology["Chromatin Topology"]
    DNA_DAMAGE -->|"contributes to"| Follicular_Atresia["Follicular Atresia"]
    DNA_DAMAGE -->|"transports"| T_CELL["T CELL"]
    DNA_DAMAGE -->|"transports"| T_CELLS["T CELLS"]
    DNA_DAMAGE -->|"transports"| TUMOR["TUMOR"]
    DNA_DAMAGE -->|"interacts"| EGF["EGF"]
    DNA_DAMAGE -->|"interacts"| HMGB1["HMGB1"]
    DNA_DAMAGE -->|"activates"| JNK["JNK"]
    miR_139_5p_Mimic["miR-139-5p Mimic"] -->|"causes"| DNA_DAMAGE
    CSNK2A1["CSNK2A1"] -->|"regulates"| DNA_DAMAGE
    NOTCH1["NOTCH1"] -->|"regulates"| DNA_DAMAGE
    oxidative_stress["oxidative stress"] -->|"causes"| DNA_DAMAGE
    Oxidative_Stress["Oxidative Stress"] -->|"causes"| DNA_DAMAGE
    GSK2606414["GSK2606414"] -.protects against.-> DNA_DAMAGE
    TFEB["TFEB"] -->|"inhibits"| DNA_DAMAGE
    TDP_43_mislocalization["TDP-43 mislocalization"] -->|"activates"| DNA_DAMAGE
    CGAS["CGAS"] -->|"causes"| DNA_DAMAGE
    AUTOPHAGY["AUTOPHAGY"] -->|"transports"| DNA_DAMAGE
    CANCER["CANCER"] -->|"transports"| DNA_DAMAGE

Outgoing (84)

Target	Relation	Type	Str
Transcription	associated_with	process	0.95
Neuronal Functions	causes	phenotype	0.95
Transcription	inhibits	process	0.95
Neurodegeneration	risk_factor_for	disease	0.95
STING Pathway	activates	pathway	0.90
Neuroinflammation	contributes_to	process	0.90
Neuronal Aging	contributes_to	process	0.90
Neuronal Aging	risk_factor_for	process	0.90
cGAS-STING signaling	activates	pathway	0.90
p53 Phosphorylation	activates	process	0.90
neuropathology	contributes_to	disease	0.90
PARP1	activates	enzyme	0.90
Apoptosis	contributes_to	process	0.90
APOPTOSIS	promotes	process	0.90
KIAA0247	upregulates	gene	0.90
aging	promotes	process	0.90
STING pathway	activates	pathway	0.87
ribosome biogenesis	modulates	process	0.85
Neuroinflammation	contributes_to	process	0.85
Aging	contributes_to	process	0.85
Chromatin Topology	associated_with	process	0.85
STING	activates	protein	0.85
Brain Aging	contributes_to	process	0.85
Genome Instability	associated_with	phenotype	0.85
Follicular Atresia	contributes_to	process	0.80
Aging	causes	process	0.80
Neurodegeneration	contributes_to	process	0.80
NEURODEGENERATION	contributes_to	process	0.80
Motor Neuron Death	causes	process	0.80
cGAS	induces	protein	0.80
oligodendrocyte degeneration	causes (DNA damage in oligodendrocytes precedes amyloid pa)	mechanism	0.75
oligodendrocyte degeneration	associated_with	phenotype	0.70
Parkinson's disease	associated_with	disease	0.70
PARP1 activation	activates	mechanism	0.70
oligodendrocyte degeneration	causes	mechanism	0.70
amyloid pathology	precedes	mechanism	0.70
brain aging	associated_with	phenotype	0.70
brain aging	risk_factor_for	phenotype	0.70
Microrna	regulates	pathway	0.50
Microrna	inhibits	pathway	0.50
GLIOSIS	activates	concept	0.50
DENDRITIC SPINE	inhibits	concept	0.50
Cellular Senescence	associated_with	cell_type	0.50
OLIGODENDROCYTES	activates	concept	0.50
IPSC	activates	concept	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
CYTOKINE	activates	concept	0.50
Cognitive Decline	associated_with	disease	0.50
Infection	associated_with	disease	0.50
Dna Damage Response	associated_with	pathway	0.50

Incoming (227)

Source	Relation	Type	Str
SMARCAL1	inhibits	gene	0.95
etoposide	causes	drug	0.95
23684800	promotes	paper	0.90
19371326	results in activation of	paper	0.90
Prmt Inhibition	upregulates	mechanism	0.90
23684800	directly leads to	paper	0.90
38596783	triggers	paper	0.90
cigarette smoke	causes	phenotype	0.90
ROS	causes	metabolite	0.90
Top1 Cleavage Complexes	contributes_to	mechanism	0.90
SNCA	causes	protein	0.90
R-Loop	causes	mechanism	0.90
miR-139-5p Mimic	causes	compound	0.90
24721741	is activated via	paper	0.90
29328926	caused	paper	0.90
PRMT suppression	promotes	process	0.90
32005289	accumulates in	paper	0.90
PRMT inhibition	associated_with	process	0.88
R-Loop Deregulation	contributes_to	mechanism	0.85
Alpha-Synuclein	causes	protein	0.85
mitochondrial_dysfunction	causes	mechanism	0.85
Oxidative Stress	causes	process	0.85
SNCA	causes	gene	0.85
Single-Stranded Dna	associated_with	compound	0.85
SNCA	causes	protein	0.85
PARP1	involved_in	protein	0.85
SOD1	associated_with	protein	0.85
SOD1 Aggregation	contributes_to	process	0.85
CSNK2A1	regulates	protein	0.85
Redox Stress	causes	process	0.85
NOTCH1	regulates	protein	0.85
Single-Stranded DNA	associated_with	compound	0.85
GABARAPL1	protects_against	gene	0.85
Aging	causes	process	0.85
Helicobacter pylori	associated_with	entity	0.80
PARP1	traps	gene	0.80
SIRTUINS	modulates	protein	0.80
HERV-K	causes	gene	0.80
PARP1	activates	gene	0.80
ROS increase	causes	mechanism	0.70
oxidative stress	causes	process	0.70
GSK2606414	protects_against	drug	0.70
TFEB	inhibits	protein	0.70
TDP-43 mislocalization	activates	process	0.70
Oxidative Stress	causes	process	0.70
32005289	is present at	paper	0.60
OPTN	activates	gene	0.50
RIPK1	activates	gene	0.50
GRB2	activates	gene	0.50
Pi3K	activates	pathway	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.837	als	-
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.661	neurodegeneration	What upstream mechanisms trigger p53 act
Telomere Attrition and DNA Damage Response Activation Induce	0.520	neurodegeneration	What molecular mechanisms drive microgli
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli
DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed	0.430	neurodegeneration	How does APOE4 mechanistically increase

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning DNA DAMAGE in their description or question text

No additional research found