entity

RAG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

17Hypotheses

0Analyses

1Outgoing

1Incoming

13Experiments

0Debates

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Wiki Pages (12)

Knowledge base pages for this entity

Outgoing (1)

Target	Relation	Type	Str
MTORC1	activates	protein	0.95

Incoming (1)

Source	Relation	Type	Str
GATOR1	inhibits	protein	0.95

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-Specific Proteolytic Fragment Inhibition Therapy	0.777	alzheimers	-
SASP-Secreted MMP-9 from Senescent Microglia Generates Patho	0.718	als	What are the mechanisms by which microgl
Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu	0.705	-	What blood-brain barrier permeability ch
Microglial Efferocytosis Enhancement via GPR32 Superagonists	0.704	neurodegeneration	Neuroinflammation resolution mechanisms
CSF Soluble TREM2 Fragment Ratio as Priming State Indicator	0.689	biomarkers	What biomarkers can reliably detect micr

S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF	0.647	-	Blood-brain barrier permeability changes
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.613	neurodegeneration	What are the mechanisms by which gut mic
TBK1 Loss Drives Microglial Senescence-SASP to Generate MMP-	0.499	als	What are the mechanisms by which microgl
Soluble LRP1 Fragments Serve as Blood-Based Indicators of Im	0.485	-	What blood-brain barrier permeability ch
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r
CSF TREM2 Fragment Ratio Integrated with Neuroinflammatory C	0.380	biomarkers	What biomarkers can reliably detect micr
RAGE-Mediated Transcytotic Pump Enhancement Strategy	0.380	neuropharmacology	What is the actual quantitative contribu
Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Sign	0.380	synaptic-biology	What determines the selectivity of compl
TBK1 Loss Drives MMP-9-Mediated TDP-43 Fragmentation Through	0.376	als	What are the mechanisms by which microgl
Site-Specific TREM2 Fragment Analysis Within Multi-Analyte C	0.368	biomarkers	What biomarkers can reliably detect micr
Dual-Signal Model: PS + Tau N-terminal Fragments Enable Sele	0.000	-	Does tau aggregation specifically cause
Engineered Exosome-Encapsulated Antibody Fragments	0.000	-	Blood-brain barrier transport mechanisms

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (13)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
GWAS of plasma NfL in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma pTau217 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
Dairy intake and dementia risk in Malmö Diet and Cancer cohort	clinical	Alzheimer's disease	0.950	0.00	Swedish community-based adults	proposed	N/A
GWAS of composite biomarker score	exploratory	Alzheimer's disease	0.900	0.00	human patients - East Asian co	proposed	N/A
AGE-mediated HCC induction in animal models with β-catenin signaling	validation	Hepatocellular carcinoma	0.900	0.00	animal models (species not spe	proposed	N/A
Proximity labeling approach combined with proteomics identified subcel	computational	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Single-nucleus RNA sequencing of temporal neocortex showed nominally i	gene_expression	Alzheimer's disease	0.500	0.00	in_vivo	extracted	N/A
iPSC-derived AD model with optical electrophysiology enabled mechanist	cell_biology	Alzheimer's disease	0.500	0.00	ipsc	extracted	N/A
Phosphorylated mTOR levels in spheroids correlated with AD severity in	neuropathology	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Proximity labeling proteomics in mouse brains revealed similar spheroi	computational	Alzheimer's disease	0.500	0.00	mouse	extracted	N/A
Proximity labeling proteomics of axonal spheroids in human postmortem	computational	Alzheimer's disease	0.500	0.00	in_vivo	extracted	N/A
s:** - GPR32 knockout in microglia should worsen neuroinflammation if	falsification	Neuroinflammation	0.400	0.50	cell_line	proposed	$80,000
FTD Microglia Role: Protective vs Destructive Mechanism Study	validation	Neuroinflammation	0.400	0.50	human	proposed	$2,960,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in dia [PMID:41054305]	Xiong Y, Li R, Chen X, Peng C, Zeng Q, Z	Mol Ther	2026	1
Chemerin-CMKLR1 differentially mediated OGD/R-induced mitochondrial dysfunction, [PMID:41151300]	Long PY, Tang Z, Cai N, Yan ZQ, Gao X, W	Biomed Pharmacother	2025	1
The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/I [PMID:34330814]	Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B,	Sci Immunol	2021	1
Microglial Aβ receptors in Alzheimer's disease. [PMID:25149075]	Yu Y, Ye RD	Cell Mol Neurobiol	2015	1
Decoding cell death signals in liver inflammation. [PMID:23567086]	Brenner C, Galluzzi L, Kepp O, Kroemer G	J Hepatol	2013	1
Molecular Signaling and Biased Agonism of the CHEMR23 Receptor: Implications for [PMID:41486998]	["Neprelyuk O", "Romanenko I", "Irza O",	Current protein & peptide scie	2026	0
Receptor-Mediated Shuttling of a D-Amino Acid Peptide Achieves High Nanomolar Cy [PMID:41422545]	["List M", "Beck-Sickinger A"]	Journal of the American Chemic	2026	0
Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function [PMID:41678947]	Lin YC, Igarashi M, Sakai Y, Nishikawa M	Biochem Biophys Res Commun	2026	0
Follicle-dependent differential localization of adipokines in the letrozole-indu [PMID:41857436]	["Dutta A", "Gurusubramanian G", "Roy V"	Histochemistry and cell biolog	2026	0
Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Mid [PMID:41538650]	["Zhu Z", "Du F", "Liu Y", "Yang J", "Ge	Advanced science (Weinheim, Ba	2026	0
Decoding microglial immunometabolism: a new frontier in Alzheimer's disease rese [PMID:40149001]	Jung ES, Choi H, Mook-Jung I	Molecular neurodegeneration	2025	0
Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis [PMID:38917486]	Zhang N, Chen P, Liang X, Sun J, Liu Q,	Aging	2024	0
Updates in Alzheimer's disease: from basic research to diagnosis and therapies. [PMID:39232848]	Liu E, Zhang Y, Wang JZ	Transl Neurodegener	2024	0
Updates in Alzheimer's disease: from basic research to diagnosis and therapies. [PMID:39232848]	Liu E, Zhang Y, Wang JZ	Translational neurodegeneratio	2024	0
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic li [PMID:38297127]	Fan W, Adebowale K, Váncza L, Li Y, Rabb	Nature	2024	0
Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming a [PMID:36154605]	["Koerich S", "Parreira G", "de Almeida	Current neuropharmacology	2023	0
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR [PMID:37442582]	Strickson S, Houslay KF, Negri VA, Ohne	The European respiratory journ	2023	0
Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary a [PMID:36600187]	["Sanges S", "Rice L", "Tu L", "Valenzi	Annals of the rheumatic diseas	2023	0
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology a [PMID:36201573]	Unknown	Science	2022	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAG in their description or question text

S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF-κB/Claudin-5 Axis

Score: 0.647 · unknown disease · 2026-04-26

S100B operates as a pathogenic DAMP in the perivascular space, binding RAGE on brain endothelial cells to trigger NF-κB-

Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade

Score: 0.613 · neurodegeneration · 2026-04-02

## Mechanistic Overview Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade starts from the

TBK1 Loss Drives Microglial Senescence-SASP to Generate MMP-9-Mediated TDP-43 C-

Score: 0.499 · als · 2026-04-27

This hypothesis proposes that TBK1 loss-of-function mutations initiate a pathological cascade where microglia become loc

Soluble LRP1 Fragments Serve as Blood-Based Indicators of Impaired Aβ Efflux and

Score: 0.485 · unknown disease · 2026-04-26

LRP1 at brain microvascular endothelium mediates Aβ export from CNS to periphery. AD-associated inflammation activates A

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

Score: 0.442 · neurodegeneration · 2026-04-22

## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts

CSF TREM2 Fragment Ratio Integrated with Neuroinflammatory Cascade Markers

Score: 0.380 · biomarkers · 2026-04-27

Site-specific TREM2 cleavage fragments (N-terminal vs C-terminal ratios) serve as the primary readout for microglial pri

RAGE-Mediated Transcytotic Pump Enhancement Strategy

Score: 0.380 · neuropharmacology · 2026-04-27

The RAGE-Mediated Transcytotic Pump Enhancement Strategy proposes that therapeutic antibody delivery to the CNS can be o

Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Signaling

Score: 0.380 · synaptic-biology · 2026-04-27

The astrocyte-mediated synaptic tagging mechanism operates through coordinated CREB1, S100B, and RAGE (receptor for adva

TBK1 Loss Drives MMP-9-Mediated TDP-43 Fragmentation Through Senescent Microglia

Score: 0.376 · als · 2026-04-26

TBK1 deficiency in microglia creates a pathological cascade that directly generates ALS-driving TDP-43 pathology through

Site-Specific TREM2 Fragment Analysis Within Multi-Analyte CSF Panel for Microgl

Score: 0.368 · biomarkers · 2026-04-26

This hypothesis proposes that incorporating Parent B's mechanistically precise site-specific TREM2 fragment ratio analys

Dual-Signal Model: PS + Tau N-terminal Fragments Enable Selective Targeting

Score: 0.000 · unknown disease · 2026-04-28

PS exposure alone is insufficient for selective tau targeting; a dual-signal mechanism exists where externalized PS recr

Engineered Exosome-Encapsulated Antibody Fragments

Score: 0.000 · unknown disease · 2026-04-28

Package anti-amyloid scFv fragments or nanobodies within engineered exosomes expressing brain-targeting ligands (transfe

RAG

Understanding Entity Pages

Wiki Pages (12)

RRAGB — Ras-Related GTP Binding B

AGER/RAGE Protein

RRAGA — Ras-Related GTP Binding A

RAGE Gene

RAGE (Receptor for Advanced Glycation End Products) Modulator Therapy

Section 227: Advanced Glycation End Products and RAGE Therapy in CBS/PSP