protein 931 words KG: RAGE 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

RAGE (Receptor for Advanced Glycation End Products)

🔬 Protein Info
Gene SymbolRAGE
AliasesReceptor for Advanced Glycation End Products
Protein TypeReceptor
FunctionIn the healthy nervous system, RAGE participates in: - Development: Neuronal differentiation and migration during embryonic development - Repair: Tissue repair and regeneration following injury - Infl
Primary Expressionhippocampus, cortex, spinal cord, Thalamus, Hypothalamus
Subcellular Localization</th><td>Cell surface (membrane), cytoplasm, nucleus</td></tr>
Molecular Weight45 kDa
PathwaysNF-κB, MAPK pathway, NF-κB signaling
GeneCardsRAGE
Human Protein AtlasRAGE
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
Known Drugs/CompoundsRAPAMYCIN, RESVERATROL, resveratrol, metformin
InteractionsTLR4, CD14, CD47, CMKLR1, TLR2, APP
KG Connections1090 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Glymphatic-Cholinergic Tau Clearance Cascade
Score: 0.43
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (4)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
AIFM1 Gene
gene · KG edge: expressed_in
acetylcholine
general · KG edge: regulates

Knowledge Graph (12 edges)

RAGE interacts_with TLR4
RAGE interacts_with CD14
RAGE associated_with CD36
RAGE interacts_with CD47
RAGE activates CMKLR1
RAGE interacts_with TLR2
RAGE therapeutic_target STING
RAGE inhibits APP
RAGE therapeutic_target CGAS
RAGE therapeutic_target VDAC1