gene 2,350 words KG: RRAGA 2026-03-27
kind:genesection:genesstate:published
Contents

RRAGA — Ras-Related GTP Binding A

🧬 Gene Info
Gene SymbolRRAGA
Full NameRas-Related GTP Binding A
Chromosome9p21.1
Functionis a member of the Rag GTPase family that plays a central role in regulating the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway<sup>[1]</sup>.
PathwaysmTOR, mtor
UniProt ID[Q9Y282](https://www.uniprot.org/uniprot/Q9Y282)
Ensembl IDENSG00000136996
OMIM608456
GeneCardsRRAGA
Human Protein AtlasRRAGA
GxxxxGKST motifPhosphate-binding loop (P-loop) for nucleotide binding
NKXD motifSpecific to GTPases, involved in GDP/GTP binding
Switch I regionUndergoes conformational changes between GDP/GTP states
Switch II regionCritical for effector interactions
C-terminal regionMediates dimerization with RagC/D
Associated DiseasesCancer, Carcinoma
InteractionsG3BP1, JUN, MAPT, RRAGB, TIA1, EIF2A
KG Connections60 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (5)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (12)

Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: interacts_with
ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: interacts_with
MAPT (Microtubule-Associated Protein Tau) Gene
gene · KG edge: interacts_with
JUN Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

RRAGA interacts_with G3BP1
RRAGA interacts_with JUN
RRAGA interacts_with MAPT
RRAGA interacts_with RRAGB
RRAGA interacts_with TIA1
RRAGA interacts_with EIF2A
RRAGA associated_with NFAT5
RRAGA associated_with WIPI2
RRAGA interacts_with FMR1
RRAGA interacts_with TAU