| Gene Symbol | RAGE |
| Aliases | Receptor for Advanced Glycation End Products |
| Protein Type | Receptor |
| Function | In the healthy nervous system, RAGE participates in: - Development: Neuronal differentiation and migration during embryonic development - Repair: Tissue repair and regeneration following injury - Infl |
| Primary Expression | hippocampus, cortex, spinal cord, Thalamus, Hypothalamus |
| Molecular Weight | 45 kDa |
| Pathways | NF-κB, MAPK pathway, NF-κB signaling |
| GeneCards | RAGE |
| Human Protein Atlas | RAGE |
| Advanced Glycation End-products (AGEs) | Products of non-enzymatic glycation that accumulate with aging and diabetes |
| HMGB1 | High mobility group box 1 protein released from damaged cells |
| S100 proteins | Calcium-binding proteins released during inflammation |
| Phosphatidylserine | Exposed on apoptotic cells[@bianchi2011] |
| [NF-κB](/entities/nf-kb) pathway | Leads to increased expression of inflammatory cytokines |
| MAPK pathways | Including p38, JNK, and ERK |
| Associated Diseases | ALS, Aging, Alzheimer, Atherosclerosis, Cancer |
| Known Drugs/Compounds | RAPAMYCIN, RESVERATROL, resveratrol, metformin |
| Interactions | TLR4, CD14, CD47, CMKLR1, TLR2, APP |
| KG Connections | 1090 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |