protein

RORCPROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RORCPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	RORCPROTEIN
Protein Type	Receptor
Function	is a member of the nuclear receptor superfamily of ligand-dependent transcription factors.
Primary Expression	various tissues including liver, adipose tissue, and muscle, while RORγt (isoform 2, also known as RORγt in mice or RORγ2 in humans) is primarily expr
Subcellular Localization	signal (NLS) and is a target for post-translational modifications[@moras1999]
Molecular Weight	56 kDa
GeneCards	RORCPROTEIN
Human Protein Atlas	RORCPROTEIN
Hinge Region (D Domain)	Flexible region connecting the DBD to the LBD; contains the nuclear localization signal (NLS) and is a target for post-translational modifications[@moras1999].
C-terminal F Domain	Variable in length and sequence among nuclear receptors; its function in RORγ is less well characterized[@nagy1999].
[Tau](/proteins/tau) pathology	Circadian disruption is common in AD patients, and RORγ dysfunction may contribute to altered circadian gene expression that affects tau phosphorylation and aggregation[@song2020].
Neuroinflammation	RORγ promotes pro-inflammatory cytokine production by microglia and astrocytes. RORγ antagonists reduce neuroinflammation in mouse models of AD, suggesting therapeutic potential[@cunningham2019].
Synaptic plasticity	RORγ regulates genes involved in synaptic function including synapsins, PSD95, and glutamate receptors. RORγ deficiency impairs synaptic plasticity and memory formation[@huang2021].
Cholesterol metabolism	RORγ is sensitive to cholesterol-derived ligands and regulates cholesterol homeostasis in the brain. Dysregulated cholesterol metabolism is implicated in AD pathogenesis[@wang2018].
Associated Diseases	neurodegeneration
Known Drugs/Compounds	paeoniflorin
Interactions	AHR, Cytokine, CYTOKINES, FOXP3, IL-22, STAT3
KG Connections	62 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RORγ Protein

protein · 2123 words

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Pathway Diagram

graph TD
    RORCPROTEIN["RORCPROTEIN"]
    neurodegeneration["neurodegeneration"]
    RORCPROTEIN -->|"implicated_in"| neurodegeneration
    style RORCPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning RORCPROTEIN in their description or question text

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