protein

RYR2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RYR2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

RyR2 is a homotetrameric calcium release channel of ~2.2 MDa located in the endoplasmic reticulum (ER) membrane<sup>[1]</sup>. Each subunit is 4,967 amino acids.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	RYR2PROTEIN
Protein Type	Channel
Function	is a homotetrameric calcium release channel of ~2.
Primary Expression	hippocampal neurons, cortical pyramidal cells, and other neuronal populations<sup>[2]<
Subcellular Localization	** \| ER/SR membrane \|
Molecular Weight	565 kDa
Amino Acids	967 aa
GeneCards	RYR2PROTEIN
Human Protein Atlas	RYR2PROTEIN
CICR amplification	Small Ca²⁺ influx through NMDA receptors or voltage-gated Ca²⁺ channels triggers RyR2 opening, amplifying the signal
Synaptic plasticity	Essential for long-term potentiation (LTP) and long-term depression (LTD) in hippocampus
Dendritic Ca²⁺ waves	RyR2-mediated calcium waves propagate along dendrites, influencing synaptic integration
Presynaptic release	Enhances neurotransmitter vesicle fusion through presynaptic Ca²⁺ amplification
Nuclear Ca²⁺ signaling	ER-nuclear envelope continuity allows RyR2-mediated Ca²⁺ to activate nuclear CREB and gene transcription
Ca²⁺	Low cytoplasmic Ca²⁺ activates; high Ca²⁺ inhibits (bell-shaped response)
Associated Diseases	Aging, Als, cancer, Cardiac
Interactions	AND, APOPTOSIS, ASTROCYTE, ASTROCYTES, BRAIN INJURY, DRP1
KG Connections	92 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ryanodine Receptor 2 (RyR2 Protein)

protein · 637 words

→

Pathway Diagram

graph TD
    RYR2PROTEIN["RYR2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    RYR2PROTEIN -->|"implicated_in"| neurodegeneration
    style RYR2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RYR2PROTEIN in their description or question text

No additional research found