| Gene Symbol | RYR2PROTEIN |
| Protein Type | Channel |
| Function | is a homotetrameric calcium release channel of ~2. |
| Primary Expression | hippocampal neurons, cortical pyramidal cells, and other neuronal populations<sup>[2]< |
| Subcellular Localization | ** | ER/SR membrane | |
| Molecular Weight | 565 kDa |
| Amino Acids | 967 aa |
| GeneCards | RYR2PROTEIN |
| Human Protein Atlas | RYR2PROTEIN |
| CICR amplification | Small Ca²⁺ influx through NMDA receptors or voltage-gated Ca²⁺ channels triggers RyR2 opening, amplifying the signal |
| Synaptic plasticity | Essential for long-term potentiation (LTP) and long-term depression (LTD) in hippocampus |
| Dendritic Ca²⁺ waves | RyR2-mediated calcium waves propagate along dendrites, influencing synaptic integration |
| Presynaptic release | Enhances neurotransmitter vesicle fusion through presynaptic Ca²⁺ amplification |
| Nuclear Ca²⁺ signaling | ER-nuclear envelope continuity allows RyR2-mediated Ca²⁺ to activate nuclear CREB and gene transcription |
| Ca²⁺ | Low cytoplasmic Ca²⁺ activates; high Ca²⁺ inhibits (bell-shaped response) |
| Associated Diseases | Aging, Als, cancer, Cardiac |
| Interactions | AND, APOPTOSIS, ASTROCYTE, ASTROCYTES, BRAIN INJURY, DRP1 |
| KG Connections | 92 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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