Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIGMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SIGMA1 (SIGMAR1) |
| Full Name | Sigma Non-Opioid Intracellular Receptor 1 |
| Chromosome | 9p13.3 |
| Protein Type | Chaperone |
| Function | The Sigma-1 receptor exhibits diverse biological functions |
| Primary Expression | Endoplasmic reticulum, plasma membrane, mitochondria-associated membranes |
| Molecular Weight | 25 kDa |
| Amino Acids | 223 aa |
| Gene Type | Protein coding |
| UniProt ID | Q99720 |
| NCBI Gene ID | 10280 |
| Ensembl ID | ENSG00000147955 |
| OMIM | 601978 |
| E102Q | Missense |
| L95del | Deletion |
| Associated Diseases | Neurodegenerative Diseases, disease |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SIGMA1["<b>SIGMA1</b>"]
Alzheimer{"Alzheimer"}
SIGMA1 -->|"therapeutic_target"| Alzheimer
Neuroinflammation{"Neuroinflammation"}
SIGMA1 -->|"therapeutic_target"| Neuroinflammation
Inflammation{"Inflammation"}
SIGMA1 -->|"biomarker_for"| Inflammation
NEUROGRANIN(["NEUROGRANIN"])
SIGMA1 -->|"therapeutic_target"| NEUROGRANIN
ALZHEIMER(["ALZHEIMER"])
ALZHEIMER -->|"therapeutic_target"| SIGMA1
TREM2(["TREM2"])
TREM2 -->|"therapeutic_target"| SIGMA1
style SIGMA1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | therapeutic_target | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Alzheimer | biomarker_for | disease | 0.65 |
| Neuroinflammation | biomarker_for | disease | 0.65 |
| Inflammation | biomarker_for | disease | 0.65 |
| NEUROGRANIN | therapeutic_target | gene | 0.60 |
| NEUROGRANIN | biomarker_for | gene | 0.60 |
| TREM2 | biomarker_for | gene | 0.60 |
| TREM2 | therapeutic_target | gene | 0.60 |
| Neuron | therapeutic_target | cell_type | 0.60 |
| NEUROINFLAMMATION | biomarker_for | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| Α-Synuclein | therapeutic_target | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Neurodegenerative Diseases | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | therapeutic_target | gene | 0.60 |
| NEUROGRANIN | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||