Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SRSF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SRSF2 |
| Full Name | Serine and Arginine Rich Splicing Factor 2 |
| Aliases | Serine/arginine-rich splicing factor 2 |
| Chromosome | 17q25.2 |
| Protein Type | Gene |
| Function | SRSF2 encodes serine/arginine-rich splicing factor 2 (SC35), a member of the SR family of splicing factors. |
| Primary Expression | all tissues |
| Subcellular Localization | , RNA-binding properties, and protein interactions. This post-translational modification is essential for cycling betwee |
| Molecular Weight | 25 kDa |
| Amino Acids | 248 aa |
| Gene Type | Protein-coding |
| UniProt ID | P84103 |
| NCBI Gene ID | Gene ID: 6427 |
| GeneCards | SRSF2 |
| Human Protein Atlas | SRSF2 |
| Associated Diseases | ALS |
| Interactions | BRAF, TET2, SRPK1, SRSF1, ASXL1, DNMT3A |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SRSF2["SRSF2<br/>Serine/Arginine-rich<br/>Splicing Factor 2"]
SRPK1["SRPK1<br/>SRSF Protein Kinase 1"]
CLK1["CLK1<br/>CDC-like Kinase 1"]
PRE_MRNA["Pre-mRNA<br/>Substrates"]
SPLICING["Alternative<br/>Splicing"]
MATURE_MRNA["Mature mRNA<br/>Isoforms"]
NEURONAL_MRNA["Neuronal-specific<br/>mRNA Processing"]
SYNAPTIC_PROTEINS["Synaptic Protein<br/>Expression"]
NEURONAL_FUNCTION["Neuronal Function<br/>and Connectivity"]
SPLICING_DYSREG["Splicing<br/>Dysregulation"]
ABERRANT_ISOFORMS["Aberrant Protein<br/>Isoforms"]
NEURONAL_STRESS["Neuronal<br/>Stress"]
NEURODEGENERATION["Neurodegeneration<br/>and Cell Death"]
ALS_FTD["ALS/FTD<br/>Pathology"]
PROTEIN_AGGREGATES["Protein<br/>Aggregation"]
SRPK1 -->|"phosphorylates"| SRSF2
CLK1 -->|"phosphorylates"| SRSF2
PRE_MRNA --> SPLICING
SRSF2 -->|"regulates"| SPLICING
SPLICING --> MATURE_MRNA
MATURE_MRNA --> NEURONAL_MRNA
NEURONAL_MRNA --> SYNAPTIC_PROTEINS
SYNAPTIC_PROTEINS --> NEURONAL_FUNCTION
SRSF2 -->|"mutations cause"| SPLICING_DYSREG
SPLICING_DYSREG --> ABERRANT_ISOFORMS
ABERRANT_ISOFORMS --> NEURONAL_STRESS
NEURONAL_STRESS --> NEURODEGENERATION
NEURODEGENERATION --> ALS_FTD
ABERRANT_ISOFORMS --> PROTEIN_AGGREGATES
PROTEIN_AGGREGATES --> NEURODEGENERATION
style SRSF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
style NEURONAL_FUNCTION fill:#1a3a2a,stroke:#81c784,stroke-width:2px
style SYNAPTIC_PROTEINS fill:#1a3a2a,stroke:#81c784,stroke-width:2px
style SPLICING_DYSREG fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style NEURODEGENERATION fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style PROTEIN_AGGREGATES fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style SRPK1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
style CLK1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
style ALS_FTD fill:#3a2a1a,stroke:#ffa726,stroke-width:2px| Source | Relation | Type | Str |
|---|---|---|---|
| ASXL1 | interacts_with | gene | 0.60 |
| DNMT3A | interacts_with | gene | 0.60 |
| HNRNPA1 | associated_with | gene | 0.60 |
| HNRNPA2B1 | associated_with | gene | 0.60 |
| SRSF1 | associated_with | gene | 0.60 |
| RAS | interacts_with | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| SRPK1 | phosphorylates | gene | 0.55 |
| SRSF1 | phosphorylates | gene | 0.55 |
| HNRNPA2B1 | co_expressed_with | gene | 0.50 |
| SRSF1 | co_expressed_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||