HNRNPA1

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for HNRNPA1 - Heterogeneous Nuclear Ribonucleoprotein A1

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flowchart TD
    HNRNPA1["HNRNPA1<br/>RNA-binding protein"]
    
    ALS["ALS<br/>Amyotrophic Lateral Sclerosis"]
    FTD["FTD<br/>Frontotemporal Dementia"]
    MS["Multiple Sclerosis"]
    NEURO["Neurodegeneration"]
    
    VCP["VCP<br/>Valosin-containing protein"]
    TIA1["TIA1<br/>T-cell intracellular<br/>antigen 1"]
    
    ALOX15["ALOX15<br/>Arachidonate<br/>15-lipoxygenase"]
    FERROPTOSIS["Ferroptosis<br/>Iron-dependent<br/>cell death"]
    LIPID_MET["Lipid Metabolism"]
    
    AUTOPHAGY["Autophagy<br/>Cellular clearance"]
    IMMUNITY["Innate Immunity<br/>Immune response"]
    
    USP7["USP7<br/>Ubiquitin-specific<br/>peptidase 7"]
    
    HNRNPA1 --|"activates"|--> ALS
    HNRNPA1 --|"associated_with"|--> FTD
    HNRNPA1 --|"activates"|--> MS
    HNRNPA1 --|"activates"|--> NEURO
    
    HNRNPA1 --|"associated_with"|--> VCP
    HNRNPA1 --|"associated_with"|--> TIA1
    
    HNRNPA1 --|"inhibits"|--> ALOX15
    ALOX15 --|"promotes"|--> FERROPTOSIS
    HNRNPA1 --|"inhibits"|--> FERROPTOSIS
    HNRNPA1 --|"inhibits"|--> LIPID_MET
    
    HNRNPA1 --|"expressed_in"|--> AUTOPHAGY
    HNRNPA1 --|"activates"|--> IMMUNITY
    
    HNRNPA1 --|"inhibits"|--> USP7
    
    FERROPTOSIS --|"contributes_to"|--> NEURO
    AUTOPHAGY --|"dysregulated_in"|--> ALS
    VCP --|"mutations_cause"|--> FTD
    
    style HNRNPA1 fill:#006494
    style ALS fill:#ef5350
    style FTD fill:#ef5350
    style MS fill:#ef5350
    style NEURO fill:#ef5350
    style VCP fill:#4a1a6b
    style TIA1 fill:#4a1a6b
    style ALOX15 fill:#4a1a6b
    style FERROPTOSIS fill:#ef5350
    style LIPID_MET fill:#1b5e20
    style AUTOPHAGY fill:#1b5e20
    style IMMUNITY fill:#5d4400
    style USP7 fill:#4a1a6b