gene

BRAF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRAF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

610Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

RAF kinase in MAPK signaling - neuronal development, synaptic plasticity, and neurodegeneration

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🧬 Gene Info

Gene Symbol	BRAF
Full Name	B-Raf Proto-Oncogene, Serine/Threonine Kinase
Aliases	RAF kinase in MAPK signaling
Protein Family	RAF serine/threonine kinases
Protein Type	Serine/Threonine Kinase
Function	BRAF is a serine/threonine-protein kinase that serves as a key intermediate in the RAS-RAF-MEK-ERK signaling cascade.
Molecular Weight	84.5 kDa
Amino Acids	766 aa
Pathways	MAPK, mapk
UniProt ID	[P15056](https://www.uniprot.org/uniprot/P15056)
GeneCards	BRAF
Human Protein Atlas	BRAF
Associated Diseases	AD, ALS, AMELOBLASTOMA, Cancer
Known Drugs/Compounds	encorafenib + cetuximab, SORAFENIB, TRAMETINIB, dabrafenib
Interactions	PI3K, ERK1, GNAQ, STX17, GNA11, AKT
KG Connections	610 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    BRAF["BRAF<br/>Proto-oncogene"]
    MAPK["MAPK Pathway<br/>Signal Transduction"]
    KIAA1549["KIAA1549<br/>Fusion Partner"]
    
    ALS["Amyotrophic Lateral<br/>Sclerosis (ALS)"]
    MS["Multiple Sclerosis<br/>(MS)"]
    NEURODEGENERATION["Neurodegeneration<br/>Process"]
    
    GLIOMA["Glioma<br/>Brain Tumor"]
    GLIOBLASTOMA["Glioblastoma<br/>Aggressive Glioma"]
    PEDIATRIC_GLIOMA["Pediatric Low-grade<br/>Gliomas"]
    
    SENESCENCE["Cellular<br/>Senescence"]
    TUMOR_GROWTH["Tumor Growth<br/> and Progression"]
    
    THERAPEUTIC_TARGET["Therapeutic<br/>Target"]
    BIOMARKER["Disease<br/>Biomarker"]
    
    BRAF --|"activates"|--> MAPK
    KIAA1549 --|"forms fusion with"|--> BRAF
    
    BRAF --|"activates"|--> ALS
    BRAF --|"activates"|--> MS
    BRAF --|"associated with"|--> NEURODEGENERATION
    
    BRAF --|"associated with"|--> GLIOMA
    BRAF --|"associated with"|--> GLIOBLASTOMA
    BRAF --|"biomarker for"|--> PEDIATRIC_GLIOMA
    
    BRAF --|"promotes"|--> TUMOR_GROWTH
    BRAF --|"therapeutic target for"|--> SENESCENCE
    
    BRAF --> THERAPEUTIC_TARGET
    BRAF --> BIOMARKER
    
    MAPK --|"drives"|--> TUMOR_GROWTH
    MAPK --|"contributes to"|--> NEURODEGENERATION
    
    style BRAF fill:#006494
    style MAPK fill:#4a1a6b
    style KIAA1549 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style NEURODEGENERATION fill:#ef5350
    style GLIOMA fill:#ef5350
    style GLIOBLASTOMA fill:#ef5350
    style PEDIATRIC_GLIOMA fill:#5d4400
    style SENESCENCE fill:#ef5350
    style TUMOR_GROWTH fill:#ef5350
    style THERAPEUTIC_TARGET fill:#1b5e20
    style BIOMARKER fill:#5d4400

Outgoing (453)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	activates	disease	1.00
MAPK Pathway	activates	pathway	0.95
MAPK pathway	activates	pathway	0.95
encorafenib + cetuximab	therapeutic_target	drug	0.95
RAS-MAPK signaling pathway	involved_in	pathway	0.95
Cancer	associated_with	disease	0.95
Tumor	activates	disease	0.95
Cancer	inhibits	disease	0.95
Cancer	activates	disease	0.95
Langerhans Cell Histiocytosis	associated_with	disease	0.92
mitogen-activated protein kinase pathway	activates	pathway	0.92
BRAIN TUMOURS	associated_with	entity	0.90
MAP2K1	upstream_of	protein	0.90
CRAF	interacts_with	protein	0.90
pilocytic astrocytoma	drives	disease	0.90
Mapk	activates	pathway	0.90
Ameloblastoma	associated_with	disease	0.85
hairy cell leukemia	biomarker_for	disease	0.85
Acute Myeloid Leukemia	drives	disease	0.85
Als	therapeutic_target	disease	0.85
Als	associated_with	disease	0.85
Als	inhibits	disease	0.85
Chronic Myelomonocytic Leukemia	associated_with	disease	0.80
Therapy-Related Acute Myeloid Leukemia	associated_with	disease	0.80
oxidative stress response	participates_in	pathway	0.80
Pilocytic Astrocytomas	associated_with	disease	0.80
NF1	activates	gene	0.80
GENES	activates	gene	0.80
CANCER	associated_with	gene	0.80
Glioma	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Lung Cancer	therapeutic_target	disease	0.75
Colorectal Cancer	activates	disease	0.75
Colorectal Cancer	associated_with	disease	0.75
Melanoma	associated_with	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
AMELOBLASTOMA	associated_with	disease	0.72
MAPK	activates	pathway	0.72
SMO	therapeutic_target	gene	0.70
NF1	associated_with	gene	0.70
TP53	associated_with	gene	0.70
TP53	activates	gene	0.70
EGFR	activates	gene	0.70
histiocytosis	associated_with	disease	0.70
Langerhans cell histiocytosis	biomarker_for	disease	0.70
pediatric low-grade gliomas	biomarker_for	disease	0.70
OVERVIEW	therapeutic_target	gene	0.70
Myelodysplastic Syndromes	biomarker_for	disease	0.70

Incoming (157)

Source	Relation	Type	Str
dabrafenib	inhibits	drug	0.95
Myeloid Precursor	expressed_in	cell_type	0.85
ERK	therapeutic_target	gene	0.80
ERK	activates	gene	0.80
ASXL1	interacts_with	gene	0.75
TET2	interacts_with	gene	0.75
DNMT3A	interacts_with	gene	0.75
SRSF2	interacts_with	gene	0.75
KIAA1549	interacts_with	gene	0.72
PTEN	associated_with	gene	0.70
PTEN	therapeutic_target	gene	0.70
ERK	associated_with	gene	0.70
CANCER	inhibits	gene	0.70
ERK	inhibits	gene	0.70
KRAS	interacts_with	gene	0.70
ASTROCYTES	treats	cell_type	0.65
ASTROCYTE	treats	cell_type	0.65
ASTROCYTE	interacts_with	cell_type	0.65
ASTROCYTE	causes	cell_type	0.65
IDH1	associated_with	gene	0.60
TERT	associated_with	gene	0.60
JUN	biomarker_for	gene	0.60
CIC	associated_with	gene	0.60
FUBP1	associated_with	gene	0.60
H3F3A	associated_with	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
CDK1	therapeutic_target	gene	0.60
ATRX	associated_with	gene	0.60
TP53	associated_with	gene	0.60
RB1	associated_with	gene	0.60
NF1	associated_with	gene	0.60
MTOR	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
EGFR	inhibits	gene	0.60
MET	inhibits	gene	0.60
NEIL1	activates	gene	0.60
NEIL3	activates	gene	0.60
GBM	associated_with	gene	0.60
NESTIN	expressed_in	gene	0.60
GAIN	contributes_to	gene	0.60
CDK1	regulates	gene	0.60
SMO	expressed_in	gene	0.60
ERK1	activates	gene	0.60
ARAF	implicated_in	gene	0.60
ERK1	implicated_in	gene	0.60
ERK1	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BRAF

Understanding Entity Pages

Summary

Wiki Pages (21)

BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase

RASGRP1 Gene

N-of-1 and Personalized Clinical Trial Design for CBS/PSP

Cellular Senescence in Neurodegeneration

MAP2K2 Gene

NF1 — Neurofibromin 1

Striatal Tonic Dopamine Neurons

NEIL3 Gene

Senomorphics in Neurodegeneration

RASA2 — RAS GTPase-Activating Protein 2

ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1

MEK2 Protein

CIC - Capicua Transcriptional Repressor

MEK1 Protein

ARAF Gene

H3F3A — H3.3 Histone A

ERK2 Protein

c-Raf Protein (RAF1)

YWHAQ Protein