protein

SV2APROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SV2APROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SV2A belongs to the SV2 family of synaptic vesicle proteins, which also includes SV2B and SV2C. It is the most widely expressed isoform in the brain and is essential for normal synaptic function.

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🔬 Protein Info

Gene Symbol	SV2APROTEIN
Full Name	Synaptic Vesicle Glycoprotein 2A
Protein Family	SV2 (Synaptic Vesicle Glycoprotein 2)
Function	is a transmembrane protein localized to synaptic vesicles that plays a critical role in regulating neurotransmitter release.
Primary Expression	the central nervous system:
Subcellular Localization	to synaptic vesicles that plays a critical role in regulating neurotransmitter r
Molecular Weight	~82 kDa (743 amino acids)
Amino Acids	743 aa
UniProt ID	Q9H0Y9
GeneCards	SV2APROTEIN
Human Protein Atlas	SV2APROTEIN
Associated Diseases	AD, ALS
Interactions	ANXIETY, GAP43, GFAP, Proteins, PSD95, SAPAP3
KG Connections	36 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SV2APROTEIN — AlphaFold Q9H0Y9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

sv2a-protein

protein · 1732 words

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Pathway Diagram

graph TD
    SV2APROTEIN["SV2APROTEIN"]
    neurodegeneration["neurodegeneration"]
    SV2APROTEIN -->|"implicated_in"| neurodegeneration
    style SV2APROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SV2APROTEIN in their description or question text

No additional research found