Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYN3 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Als, Depression. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | SYN3 |
| Full Name | Synapsin III |
| Chromosome | 22q12.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Cerebral cortex, Hippocampus, Synaptic terminals, Retina |
| Molecular Weight | ~63 kDa |
| Amino Acids | 580 aa |
| UniProt ID | O75907 |
| NCBI Gene ID | 8864 |
| Ensembl ID | ENSG00000185608 |
| OMIM | 600731 |
| GeneCards | SYN3 |
| Human Protein Atlas | SYN3 |
| Protein Length | 580 amino acids |
| Protein Class | Synapsin Family |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | PSD95, PDZ3 |
| Interactions | BDNF, TRKB, DEPRESSION, PSD-95, AND, Bdnf |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SYN3["<b>SYN3</b>"]
PSD95["PSD95"]
SYN3 -->|"interacts with"| PSD95
PDZ3["PDZ3"]
SYN3 -->|"interacts with"| PDZ3
Depression{"Depression"}
SYN3 -->|"activates"| Depression
Als{"Als"}
SYN3 -->|"interacts with"| Als
ALS{"ALS"}
SYN3 -->|"interacts with"| ALS
BDNF["BDNF"]
SYN3 -->|"activates"| BDNF
TRKB["TRKB"]
SYN3 -->|"activates"| TRKB
DEPRESSION["DEPRESSION"]
SYN3 -->|"activates"| DEPRESSION
Hippocampus["Hippocampus"]
SYN3 -->|"expressed in"| Hippocampus
Neuron["Neuron"]
SYN3 -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
SYN3 -->|"implicated in"| neurodegeneration
BDNF -->|"activates"| SYN3
TRKB -->|"activates"| SYN3
DEPRESSION -->|"activates"| SYN3
AND["AND"]
AND -->|"interacts with"| SYN3
style SYN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PSD95 | interacts_with | protein | 0.72 |
| PDZ3 | interacts_with | protein | 0.68 |
| Depression | activates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| BDNF | activates | gene | 0.60 |
| TRKB | activates | gene | 0.60 |
| DEPRESSION | activates | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Bdnf | activates | protein | 0.60 |
| App | activates | protein | 0.60 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| PSD-95 | interacts_with | protein | 0.50 |
| NEURONS | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | activates | gene | 0.60 |
| TRKB | activates | gene | 0.60 |
| DEPRESSION | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||