gene

SYN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections
0Hypotheses
0Analyses
16Outgoing
4Incoming

Summary

SYN3 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Als, Depression. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSYN3
Full NameSynapsin III
Chromosome22q12.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionCerebral cortex, Hippocampus, Synaptic terminals, Retina
Molecular Weight~63 kDa
Amino Acids580 aa
UniProt IDO75907
NCBI Gene ID8864
Ensembl IDENSG00000185608
OMIM600731
GeneCardsSYN3
Human Protein AtlasSYN3
Protein Length580 amino acids
Protein ClassSynapsin Family
Associated Diseasesneurodegeneration
Known Drugs/CompoundsPSD95, PDZ3
InteractionsBDNF, TRKB, DEPRESSION, PSD-95, AND, Bdnf
KG Connections20 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SYN3 — AlphaFold O75907 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

SYN3 — Synapsin III

gene · 795 words

SYNA — Synapsin I

gene · 1293 words

Synapsin-2 Protein

protein · 1098 words

DLG4 Gene

gene · 1025 words

SYN3 Protein

protein · 997 words

SYN1 (Synapsin-1)

gene · 978 words

Pathway Diagram

graph TD
    SYN3["<b>SYN3</b>"]
    PSD95["PSD95"]
    SYN3 -->|"interacts with"| PSD95
    PDZ3["PDZ3"]
    SYN3 -->|"interacts with"| PDZ3
    Depression{"Depression"}
    SYN3 -->|"activates"| Depression
    Als{"Als"}
    SYN3 -->|"interacts with"| Als
    ALS{"ALS"}
    SYN3 -->|"interacts with"| ALS
    BDNF["BDNF"]
    SYN3 -->|"activates"| BDNF
    TRKB["TRKB"]
    SYN3 -->|"activates"| TRKB
    DEPRESSION["DEPRESSION"]
    SYN3 -->|"activates"| DEPRESSION
    Hippocampus["Hippocampus"]
    SYN3 -->|"expressed in"| Hippocampus
    Neuron["Neuron"]
    SYN3 -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    SYN3 -->|"implicated in"| neurodegeneration
    BDNF -->|"activates"| SYN3
    TRKB -->|"activates"| SYN3
    DEPRESSION -->|"activates"| SYN3
    AND["AND"]
    AND -->|"interacts with"| SYN3
    style SYN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

TargetRelationTypeStr
PSD95interacts_withprotein0.72
PDZ3interacts_withprotein0.68
Depressionactivatesdisease0.65
Alsinteracts_withdisease0.65
ALSinteracts_withdisease0.65

Incoming (4)

SourceRelationTypeStr
BDNFactivatesgene0.60
TRKBactivatesgene0.60
DEPRESSIONactivatesgene0.60
ANDinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found