protein

SYT1PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SYT1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	SYT1PROTEIN
Function	is a 421-amino acid synaptic vesicle membrane protein that functions as the primary calcium sensor for fast synchronous neurotransmitter release in neurons.
Subcellular Localization	</strong></td><td>Synaptic vesicle membrane (presynaptic terminal)</td></tr>
GeneCards	SYT1PROTEIN
Human Protein Atlas	SYT1PROTEIN
Single transmembrane helix	Anchors the protein to the synaptic vesicle membrane
Luminal domain	Short N-terminal segment inside the synaptic vesicle
Cytosolic tail	Long C-terminal region containing the C2 domains (exposed to cytoplasm)
β-sandwich fold	Classic C2 domain topology with 8 β-strands
Ca²⁺-binding sites	Three Ca²⁺-binding loops coordinating 3 Ca²⁺ ions
Membrane binding	Binds phosphatidylserine and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂]
SNARE complex interaction	Interacts with syntaxin-1A and SNAP-25 via this domain
Polybasic region	K-rich motif for membrane and PI(4,5)P₂ binding
Self-association	C2B mediates SYT1 dimerization — essential for synchronous release
Homology with C2A	Similar β-sandwich fold but distinct binding properties
Associated Diseases	Alzheimer, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACTB, Actin, AD, ALZHEIMER, ALZHEIMER DISEASE, AMPK
KG Connections	229 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Synaptotagmin-1 Protein

protein · 1226 words

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Pathway Diagram

graph TD
    SYT1PROTEIN["SYT1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    SYT1PROTEIN -->|"implicated_in"| neurodegeneration
    style SYT1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning SYT1PROTEIN in their description or question text

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