| Gene Symbol | SYT1PROTEIN |
| Function | is a 421-amino acid synaptic vesicle membrane protein that functions as the primary calcium sensor for fast synchronous neurotransmitter release in neurons. |
| Subcellular Localization | </strong></td><td>Synaptic vesicle membrane (presynaptic terminal)</td></tr> |
| GeneCards | SYT1PROTEIN |
| Human Protein Atlas | SYT1PROTEIN |
| Single transmembrane helix | Anchors the protein to the synaptic vesicle membrane |
| Luminal domain | Short N-terminal segment inside the synaptic vesicle |
| Cytosolic tail | Long C-terminal region containing the C2 domains (exposed to cytoplasm) |
| β-sandwich fold | Classic C2 domain topology with 8 β-strands |
| Ca²⁺-binding sites | Three Ca²⁺-binding loops coordinating 3 Ca²⁺ ions |
| Membrane binding | Binds phosphatidylserine and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂] |
| SNARE complex interaction | Interacts with syntaxin-1A and SNAP-25 via this domain |
| Polybasic region | K-rich motif for membrane and PI(4,5)P₂ binding |
| Self-association | C2B mediates SYT1 dimerization — essential for synchronous release |
| Homology with C2A | Similar β-sandwich fold but distinct binding properties |
| Associated Diseases | Alzheimer, neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACTB, Actin, AD, ALZHEIMER, ALZHEIMER DISEASE, AMPK |
| KG Connections | 229 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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