protein 1,226 words KG: SYT1PROTEIN 2026-03-29
kind:proteinsection:proteinstopic:alzheimerstopic:parkinsonsstate:published
Contents

Synaptotagmin-1 Protein

🔬 Protein Info
Gene SymbolSYT1PROTEIN
Functionis a 421-amino acid synaptic vesicle membrane protein that functions as the primary calcium sensor for fast synchronous neurotransmitter release in neurons.
Subcellular Localization</strong></td><td>Synaptic vesicle membrane (presynaptic terminal)</td></tr>
GeneCardsSYT1PROTEIN
Human Protein AtlasSYT1PROTEIN
Associated DiseasesAlzheimer, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsACTB, JUN, ATG7, MAP2, SNAP25, CTSB
KG Connections188 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Complement C1q Mimetic Decoy Therapy
Score: 0.48
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47

Related Analyses (12)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (15)

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mechanism · Pages share 8 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 8 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 8 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 8 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 8 hypotheses