gene

SYT6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYT6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

8Outgoing

9Incoming

0Experiments

0Debates

Summary

SYT6 encodes a synaptic vesicle protein functioning as a calcium sensor for neurotransmitter release, with roles in synaptic plasticity and implications for neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	SYT6
Full Name	Synaptotagmin 6
Chromosome	1p36.21
Protein Family	Synaptotagmin family
Primary Expression	the central nervous system, with high levels in the cerebral cortex, hippocampus, and cerebellum
Molecular Weight	47 kDa
Amino Acids	421 aa
Exons	12
UniProt ID	Q9BQY3
NCBI Gene ID	6862
Ensembl ID	ENSG00000124615
OMIM	610578
GeneCards	SYT6
Human Protein Atlas	SYT6
Associated Diseases	Ms
Interactions	PARKINSON, PARKINSON'S DISEASE
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SYT6 — AlphaFold Q9BQY3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SYT6 (Synaptotagmin 6)

gene · 2374 words

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Pathway Diagram

graph TD
    SYT6["SYT6"]
    Inflammation{"Inflammation"}
    SYT6 -->|"therapeutic target"| Inflammation
    Als{"Als"}
    SYT6 -->|"therapeutic target"| Als
    Neuroinflammation{"Neuroinflammation"}
    SYT6 -->|"therapeutic target"| Neuroinflammation
    Parkinson{"Parkinson"}
    SYT6 -->|"activates"| Parkinson
    Ms{"Ms"}
    SYT6 -->|"associated with"| Ms
    neurodegeneration["neurodegeneration"]
    SYT6 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| SYT6
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"therapeutic target"| SYT6
    TLR4["TLR4"]
    TLR4 -->|"associated with"| SYT6
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"therapeutic target"| SYT6
    SLC6A3["SLC6A3"]
    SLC6A3 -->|"associated with"| SYT6
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"therapeutic target"| SYT6
    style SYT6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
MICROGLIA	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
SLC6A3	associated_with	gene	0.60

Incoming (9)

Source	Relation	Type	Str
genes-syt6	linked_to	wiki	1.00
genes-syt6	describes	wiki	0.90
TLR4	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
PARKINSON	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYT6 in their description or question text

No additional research found