Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SHORT-CHAIN FATTY ACIDS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SHORT-CHAIN FATTY ACIDS |
Knowledge base pages for this entity
graph TD
SHORT_CHAIN_FATTY_ACIDS["SHORT-CHAIN FATTY ACIDS"]
SHORT_CHAIN_FATTY_ACIDS -.protects against.-> Blood_Brain_Barrier["Blood-Brain Barrier"]
SHORT_CHAIN_FATTY_ACIDS -->|"mediates"| Microbiota_Brain_Axis["Microbiota-Brain Axis"]
SHORT_CHAIN_FATTY_ACIDS -->|"modulates"| Neuroinflammation["Neuroinflammation"]
SHORT_CHAIN_FATTY_ACIDS -->|"regulates"| JUNCTIONAL_COMPLEX_PROTEINS["JUNCTIONAL COMPLEX PROTEINS"]
SHORT_CHAIN_FATTY_ACIDS -->|"binds"| G_PROTEIN_COUPLED_RECEPTORS["G-PROTEIN-COUPLED RECEPTORS"]
SHORT_CHAIN_FATTY_ACIDS -->|"modulates"| Alpha_Synuclein_Aggregation["Alpha-Synuclein Aggregation"]
SHORT_CHAIN_FATTY_ACIDS -->|"risk_factor_for"| Hypertension["Hypertension"]
SHORT_CHAIN_FATTY_ACIDS -->|"modulates"| Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"]
Anaerobic_Bacterial_Fermentati["Anaerobic Bacterial Fermentation"] -->|"product_of"| SHORT_CHAIN_FATTY_ACIDS
Gut_Microbiome["Gut Microbiome"] -->|"product_of"| SHORT_CHAIN_FATTY_ACIDS
Dietary_Fiber["Dietary Fiber"] -->|"involved_in"| SHORT_CHAIN_FATTY_ACIDS
Maternal_Microbiota["Maternal Microbiota"] -->|"upregulates"| SHORT_CHAIN_FATTY_ACIDS
Parkinson_s_Disease["Parkinson's Disease"] -->|"correlates_with"| SHORT_CHAIN_FATTY_ACIDS
Probiotics["Probiotics"] -->|"upregulates"| SHORT_CHAIN_FATTY_ACIDS| Target | Relation | Type | Str |
|---|---|---|---|
| SNCA | modulates | protein | 0.95 |
| Blood-Brain Barrier | protects_against | process | 0.95 |
| Microbiota-Brain Axis | mediates | pathway | 0.90 |
| JUNCTIONAL COMPLEX PROTEINS | regulates | protein | 0.90 |
| G-PROTEIN-COUPLED RECEPTORS | binds | receptor | 0.90 |
| Alpha-Synuclein Aggregation | modulates | process | 0.90 |
| Neuroinflammation | modulates | process | 0.90 |
| Parkinson'S Disease | associated_with | disease | 0.90 |
| Microbiota-Gut-Brain Axis | modulates | pathway | 0.85 |
| Microbiota-Gut-Brain Axis | mediates | pathway | 0.85 |
| HISTONE DEACETYLASES | inhibits | enzyme | 0.85 |
| Cardiovascular Disease | risk_factor_for | disease | 0.85 |
| Gut-Brain Axis | involved_in | pathway | 0.85 |
| MTOR | modulates | gene | 0.85 |
| Hypertension | risk_factor_for | disease | 0.85 |
| Parkinson's Disease | protects_against | disease | 0.85 |
| Neuroinflammation | suppresses | process | 0.85 |
| Oxidative Stress | suppresses | process | 0.85 |
| mTOR Pathway | activates | pathway | 0.80 |
| Blood-Brain Barrier Integrity | protects_against | phenotype | 0.80 |
| neuroinflammation | suppresses | process | 0.80 |
| GPR43 | activates | receptor | 0.80 |
| GPR109A | activates | receptor | 0.80 |
| Gastrointestinal Tract | mediates | cell_type | 0.75 |
| Microglial Activation | modulates | process | 0.75 |
| NEUROINFLAMMATION | inhibits | process | 0.75 |
| Parkinson's Disease | treats | disease | 0.75 |
| Parkinson's disease | modulates | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Anaerobic Bacterial Fermentation | product_of | process | 0.95 |
| Gut Microbiome | product_of | process | 0.95 |
| Gut Microbiome | associated_with | process | 0.95 |
| Bifidobacterium | associated_with | cell_type | 0.90 |
| Dietary Fiber | involved_in | compound | 0.90 |
| Maternal Microbiota | upregulates | process | 0.90 |
| Probiotics | associated_with | drug | 0.80 |
| Parkinson's Disease | correlates_with | disease | 0.80 |
| Probiotics | upregulates | drug | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||