Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPSES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SYNAPSE |
| Full Name | Synaptic Junction (cellular structure) |
| Aliases | Synaptic cleft |
| Protein Type | Cellular structure |
| Function | Specialized intercellular junction enabling electrochemical signal transmission between neurons. Comprises presynaptic terminal, synaptic cleft, and postsynaptic density. Critical for learning, mem... |
| Pathways | Neurotransmitter release, LTP, LTD, AMPA/NMDA signaling |
| GeneCards | SYNAPSE |
| Human Protein Atlas | SYNAPSE |
| Source | Target |
| Inferior olive | Purkinje cells |
| Axon collaterals | Deep nuclei |
| Interneurons | Modulatory |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Schizophrenia, ALS |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SYNAPSES["SYNAPSES"] -->|"causes"| RAB7["RAB7"]
style RAB7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
SYNAPSES["SYNAPSES"] -->|"regulates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
style PHAGOCYTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
SYNAPSES["SYNAPSES"] -.->|"inhibits"| BDNF["BDNF"]
style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
SYNAPSES["SYNAPSES"] -->|"causes"| COMPLEMENT_ACTIVATION["COMPLEMENT ACTIVATION"]
style COMPLEMENT_ACTIVATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
SYNAPSES["SYNAPSES"] -->|"causes"| SYNAPTIC_LOSS["SYNAPTIC LOSS"]
style SYNAPTIC_LOSS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
SYNAPSES["SYNAPSES"] -.->|"inhibits"| LYSOSOME["LYSOSOME"]
style LYSOSOME fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
SYNAPSES["SYNAPSES"] -->|"causes"| NEURON["NEURON"]
style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
TREM2["TREM2"] -->|"protects against"| SYNAPSES["SYNAPSES"]
style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
MICROGLIA["MICROGLIA"] -->|"phagocytoses"| SYNAPSES["SYNAPSES"]
style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
SPP1["SPP1"] -->|"induces"| SYNAPSES["SYNAPSES"]
style SPP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
GLUTAMATE["GLUTAMATE"] -->|"produces"| SYNAPSES["SYNAPSES"]
style GLUTAMATE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"activates"| SYNAPSES["SYNAPSES"]
style OLIGODENDROCYTE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style SYNAPSES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | interacts_with | cell_type | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455
neuro-oncology | 2026-04-13 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||