gene

SYNAPSES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPSES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

8Hypotheses

2Analyses

0Outgoing

22Incoming

0Experiments

2Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SYNAPSE
Full Name	Synaptic Junction (cellular structure)
Aliases	Synaptic cleft
Protein Type	Cellular structure
Function	Specialized intercellular junction enabling electrochemical signal transmission between neurons. Comprises presynaptic terminal, synaptic cleft, and postsynaptic density. Critical for learning, mem...
Pathways	Neurotransmitter release, LTP, LTD, AMPA/NMDA signaling
GeneCards	SYNAPSE
Human Protein Atlas	SYNAPSE
Purkinje cell dendrites	Extensive dendritic tree spanning the molecular layer
Dendritic spines	Single spine innervation creating one-to-one specificity
Proximal dendrite	High-density synaptic contacts near the soma
Somatic region	Proximal dendrite contacts for powerful excitation
P/Q-type calcium channels (Cav2.1)	Mediate calcium entry triggering neurotransmitter release
Climbing fiber varicosities	En passant synapses along the axonal trajectory
Active zone proteins	RIM1/2, Munc13, and complexin coordinate release kinetics
Associated Diseases	Alzheimer's disease, Parkinson's disease, Schizophrenia, ALS
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Climbing Fiber Synapses

cell · 1553 words

→

Pathway Diagram

graph TD
    SYNAPSES["SYNAPSES"] -->|"causes"| RAB7["RAB7"]
    style RAB7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"regulates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    style PHAGOCYTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -.->|"inhibits"| BDNF["BDNF"]
    style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"causes"| COMPLEMENT_ACTIVATION["COMPLEMENT ACTIVATION"]
    style COMPLEMENT_ACTIVATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"causes"| SYNAPTIC_LOSS["SYNAPTIC LOSS"]
    style SYNAPTIC_LOSS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -.->|"inhibits"| LYSOSOME["LYSOSOME"]
    style LYSOSOME fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"causes"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"protects against"| SYNAPSES["SYNAPSES"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MICROGLIA["MICROGLIA"] -->|"phagocytoses"| SYNAPSES["SYNAPSES"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SPP1["SPP1"] -->|"induces"| SYNAPSES["SYNAPSES"]
    style SPP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GLUTAMATE["GLUTAMATE"] -->|"produces"| SYNAPSES["SYNAPSES"]
    style GLUTAMATE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"activates"| SYNAPSES["SYNAPSES"]
    style OLIGODENDROCYTE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style SYNAPSES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (22)

Source	Relation	Type	Str
Microglial Phagocytosis	targets	process	0.90
16791195	form	paper	0.90
16791195	always formed	paper	0.90
20818335	has initial toxic impact on	paper	0.90
microglia	prunes	cell_type	0.90
21240273	operates independent of	paper	0.90
38255891	are tagged with	paper	0.90
16892056	always had	paper	0.90
11127834	are involved in	paper	0.90
Microglia	associated_with	cell_type	0.90
19109909	have diverse functions at	paper	0.90
SNCA	expressed_in	protein	0.85
C1QA	associated_with	gene	0.85
Microglia	interacts_with	cell_type	0.85
microglia	targets	cell_type	0.80
astrocytes	targets	cell_type	0.75
C1Q	causes	protein	0.70
microglia	interacts_with	cell_type	0.64
MICROGLIA	interacts_with	cell_type	0.64
16481424	localizes to	paper	0.60
25855189	are fundamental to	paper	0.60
38255891	are tagged with complement proteins and consequently removed by	paper	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aberrant Galectin-3 Expression on Stressed Synapses Creates	0.610	synaptic-biology	What determines the selectivity of compl
Activity-dependent MAP6 scaffolding at synapses	0.600	neurodegeneration	-
TFEB Activation to Restore Lysosomal Biogenesis in Aged Syna	0.591	proteomics	Quantitative proteomics of the aging syn
Closed-Loop Phase-Specific Targeting of PV-to-Pyramidal Syna	0.585	alzheimers	Closed-loop optogenetic targeting PV int
C1q shows synapse-class-specific roles, with inhibitory vers	0.530	neurodegeneration	Does C1q function differ based on subcel

TFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysos	0.510	proteomics	Quantitative proteomics of the aging syn
TFEB-Mediated Autophagosome-Lysosome Fusion Enhancement in A	0.380	proteomics	Quantitative proteomics of the aging syn
LAMP1 Overexpression to Enhance Lysosomal Capacity Independe	0.000	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (2)

Scientific analyses that reference this entity

Which specific aging-related gene expression changes in mouse brain predict huma

neurodegeneration | 2026-04-11 | 0 hypotheses

Synaptic pruning by microglia in neurodegeneration

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

closed · Rounds: 4 · Score: 0.68 · 2026-04-22

The debate aimed to cross-reference Allen Aging Mouse Brain Atlas data with huma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning SYNAPSES in their description or question text

TFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysosomal Trafficking in

Score: 0.510 · proteomics · 2026-04-26

This hypothesis proposes that TFEB activation can restore synaptic function in aging by simultaneously upregulating both

TFEB-Mediated Autophagosome-Lysosome Fusion Enhancement in Aged Neuronal Synapse

Score: 0.380 · proteomics · 2026-04-27

Age-related synaptic dysfunction is characterized by accumulation of damaged organelles and misfolded proteins due to co

LAMP1 Overexpression to Enhance Lysosomal Capacity Independent of TFEB in Aged S

Score: 0.000 · proteomics · 2026-04-28

LAMP1 (Lysosomal Associated Membrane Protein 1) is a critical structural component of lysosomal membranes that directly