Synucleinopathies

Understanding Entity Pages

This page aggregates everything SciDEX knows about Synucleinopathies: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Synucleinopathies are a group of neurodegenerative disorders characterized by the abnormal accumulation of alpha-synuclein (α-syn) protein within neurons, glial cells, and extracellular spaces[@spillantini1997]. This class of diseases includes Parkinson's disease (PD), dementia with Lewy bodies (DLB

View on Wiki →

flowchart TD
    Synucleinopathies{{"Synucleinopathies"}}
    Alpha_Synuclein(["Alpha-Synuclein"])
    Alpha_Synuclein -->|"causes"| Synucleinopathies
    ALPHA_SYNUCLEIN(["ALPHA-SYNUCLEIN"])
    ALPHA_SYNUCLEIN -->|"causes"| Synucleinopathies
    SNCA(["SNCA"])
    SNCA -->|"involved in"| Synucleinopathies
    SNCA -->|"causes"| Synucleinopathies
    Synucleinopathies -->|"associated with"| SNCA
    __Synuclein_Aggregates("alpha-Synuclein Aggregates")
    __Synuclein_Aggregates -->|"biomarker for"| Synucleinopathies
    SNCA -->|"biomarker for"| Synucleinopathies
    __Synuclein_Aggregates -->|"causes"| Synucleinopathies
    SNCA -->|"associated with"| Synucleinopathies
    GCASE("GCASE")
    GCASE -->|"risk factor for"| Synucleinopathies
    DNAJB6(["DNAJB6"])
    DNAJB6 -->|"protects against"| Synucleinopathies

    style Synucleinopathies fill:#4a148c,stroke:#4fc3f7,stroke-width:3px,color:#fff