protein

alpha-synuclein

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about alpha-synuclein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1819Connections

3Hypotheses

2Analyses

30Outgoing

37Incoming

Summary

alpha-synuclein is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with Alzheimer's disease, Parkinson, Parkinson's disease. Connected to 24 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ALPHA-SYNUCLEIN
Chromosome	4q21.31
Protein Family	Synuclein family
Subcellular Localization	Presynaptic terminals, nucleus
Molecular Weight	14 kDa (140 aa)
Pathways	amyloid plaques, mTORC1, oxidative stress
UniProt ID	P37840
GeneCards	ALPHA-SYNUCLEIN
Human Protein Atlas	ALPHA-SYNUCLEIN
Structure prediction	Integrates AlphaFold2, Chai, Boltz, OpenFold, and emerging co-folding methods
Sequence-structure-function exploration	Tightly integrated visual interface for exploring protein functional determinants
Collaborative sessions	Saved sessions enable researchers to share findings with other users
Extensible architecture	Easy addition of new tools and models via the Slivka compute API
Assay data integration	Explore relationships through real experimental assay data or computational predictions
Associated Diseases	Alzheimer's disease, Lewy bodies, Parkinson, Parkinson's disease, dementia with Lewy bodies, synucleinopathies
Interactions	TSC2, TSC1-TSC2 complex, ACLY, STING1, STAT1, LAG3
KG Connections	67 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: alpha-synuclein — AlphaFold P37840 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    aSyn["alpha-Synuclein Monomer"] -->|"Misfolds"| Oligo["Oligomers"]
    Oligo -->|"Aggregates"| Fibrils["Fibrils"]
    Fibrils -->|"Form"| LB["Lewy Bodies"]
    aSyn -->|"Localizes to"| Synapse["Presynaptic Terminals"]
    Synapse -->|"Regulates"| Release["Vesicle Release"]
    Oligo -->|"Spread via"| Prion["Prion-like Mechanism"]
    Prion -->|"Cell-to-cell"| Propagation["Trans-cellular Propagation"]
    LB -.Disrupt.-> Function["Cellular Function"]
    Function -.Leads to.-> PD["Parkinson's Disease"]

Outgoing (1016)

Target	Relation	Type	Str
Lewy bodies	associated_with	phenotype	0.95
dopaminergic neurons	causes	cell_type	0.90
mTORC1	activates	pathway	0.90
ACLY	activates	protein	0.90
Parkinson	causes	disease	0.90
STAT1	activates	gene	0.90
autophagy	inhibits	process	0.90
substantia nigra	causes	brain_region	0.90
synaptic vesicles	inhibits	pathway	0.85
microglia	activates	cell_type	0.85
TSC2	interacts_with	protein	0.85
neuroinflammation	associated_with	process	0.85
TSC1-TSC2 complex	inhibits	protein	0.80
Lewy Bodies	associated_with	biological_process	0.80
mitochondrial dysfunction	interacts_with	process	0.70
Parkinson's disease	associated_with	disease	0.70
autophagy-lysosome pathway	inhibits	pathway	0.70
STING1	activates	protein	0.70
Parkinson's disease	causes	disease	0.70
STING1	regulates	protein	0.70
Alzheimer's disease	associated_with	disease	0.70
amyloid plaques	activates	process	0.70
oxidative stress	activates	process	0.70
dementia with Lewy bodies	causes	disease	0.70
neuroinflammation	promotes	process	0.70
neurodegeneration	promotes	process	0.70
apoptosis	co_discussed	concept	0.65
mitochondria	co_discussed	concept	0.65
lysosome	co_discussed	concept	0.65
synucleinopathies	implicated_in	disease	0.60

Incoming (803)

Source	Relation	Type	Str
SNCA	produces	gene	0.95
LAG3	interacts_with	protein	0.95
VINPOCETINE	attenuates	compound	0.90
PINK1	phosphorylates	gene	0.90
LAG3	facilitates	protein	0.90
BAG3	mediates_clearance	gene	0.80
BAG3	mediates	gene	0.80
VINPOCETINE	downregulates	compound	0.80
GBA	regulates	gene	0.80
NNMT	causes_aggregation_of	gene	0.80
ANTISENSE OLIGONUCLEOTIDE (ASO)	reduces_expression	compound	0.80
SNCA	encodes	gene	0.70
ubiquitin-proteasome system	regulates	pathway	0.70
autophagy-lysosome pathway	regulates	pathway	0.70
autophagy-lysosomal pathway	activates	pathway	0.70
polyamines	regulates	chemical	0.70
PARKIN	degrades	gene	0.70
pesticides	causes	drug	0.70
air pollution	causes	process	0.70
olfactory system	expressed_in	cell_type	0.70
enteric nervous system	expressed_in	cell_type	0.70
lysosomal acidification	regulates	process	0.70
microglia	interacts_with	cell_type	0.70
GBA1	regulates	gene	0.70
endoplasmic reticulum stress	promotes	process	0.70
Vulnerable Neuronal Populations	expresses	mechanism	0.70
Resistant Cells	expresses	mechanism	0.70
NRF2	co_discussed	gene	0.65
CSF1R	co_discussed	gene	0.65
GDNF	co_discussed	gene	0.65
LAMP2	co_discussed	gene	0.65
TFEB	co_discussed	gene	0.65
LRRK2	co_discussed	gene	0.65
TBK1	co_discussed	gene	0.65
CSGA	interacts_with	protein	0.60
DNAJB6	inhibits	protein	0.60
Tau	co_expressed_with	protein	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic
H7: Enteric Nervous System Alpha-Synuclein Propagation Block	0.595	neurodegeneration	How does engineered C. butyricum cross t
Neuronal Subtype-Specific Alpha-Synuclein Expression Normali	0.382	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

GBA-Synuclein Loop Therapeutics for PD

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Meta-analysis of mRNA dysregulation associated with Parkinson's disease and othe [PMID:41183391]	Lin Aung T, Aung YW, Shi X	Biomed Phys Eng Express	2026	1
A human striatal-midbrain assembloid model of alpha-synuclein propagation. [PMID:40919647]	Tran HD, Shin MK, Yeo XY, Jung S, Junaid	Brain	2026	0
Neuronal titration of Snca via enhancer disruption mitigates disease onset in a [PMID:41496593]	Boyd RJ, Kho AR, McClymont SA, Loftus SK	Brain	2026	0
Perampanel Blocks Transsynaptic α-Synuclein Propagation and Neurodegeneration in [PMID:41508763]	Ueda J, Uemura N, Chang J, Hirato T, Ish	Mov Disord	2026	0
Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 p [PMID:41574889]	Fraser KB, Mirelman A, Mabrouk OS, Omer	J Parkinsons Dis	2026	0
Aberrant Protein S-Nitrosylation Mimics the Effect of Rare Genetic Mutations in [PMID:41635116]	Wang Y, Lipton SA	J Neurochem	2026	0
SNCA triplication disrupts proteostasis and extracellular architecture prior to [PMID:41698927]	Statoulla E, Zafeiri M, Chalkiadaki K, V	NPJ Parkinsons Dis	2026	0
Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's dise [PMID:41730496]	Panda SP, Saraswat N, Singh V	Neuroscience	2026	0
Degradation of alpha-synuclein/SNCA mRNA by RNautophagy. [PMID:41747943]	Kabuta C, Hakuno F, Kataoka N, Takahashi	Neurochem Int	2026	0
An update on the monogenic causes of Parkinson's disease: Impact on patient stra [PMID:41759745]	Asmi S, Krishnan A, Alexander SM, Mohame	Ageing Res Rev	2026	0
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026	0
Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRI [PMID:41905621]	["Singh R", "Maity P", "Jaiswal C"]	Neurochemistry international	2026	0

alpha-synuclein

Understanding Entity Pages

Summary

Wiki Pages (21)

GYDE (Collaborative Protein Design Platform)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene