disease

msa

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about msa: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

1Hypotheses

1Analyses

22Outgoing

34Incoming

1Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["MSA"]
    N1["synucleinopathies"]
    N0 -->|"contributes to"| N1
    N2["alpha_synuclein"]
    N2 -->|"causes"| N0
    N3["NEURODEGENERATION"]
    N0 -->|"associated with"| N3
    N4["SCHIZOPHRENIA"]
    N0 -->|"associated with"| N4
    N5["HAND"]
    N5 -->|"associated with"| N0
    N6["ALS"]
    N6 -->|"associated with"| N0
    N7["AUTISM"]
    N7 -->|"associated with"| N0
    N8["DEPRESSION"]
    N8 -->|"associated with"| N0
    N9["EPILEPSY"]
    N9 -->|"associated with"| N0
    N10["PARKINSON"]
    N0 -->|"co discussed"| N10
    N11["PARKINSON'S"]
    N0 -->|"co discussed"| N11

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N2 protein

Outgoing (22)

Target	Relation	Type	Str
synucleinopathies	contributes_to	disease	0.76
NEURODEGENERATION	associated_with	entity	0.60
SCHIZOPHRENIA	associated_with	entity	0.60
NEURONS	co_discussed	cell_type	0.50
NEURON	co_discussed	cell_type	0.50
SNCA	co_discussed	entity	0.50
MULTIPLE SCLEROSIS	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50
P62	co_discussed	entity	0.50
PSP	co_discussed	entity	0.50
STRIATUM	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
SLEEP	co_discussed	entity	0.50
OLIGODENDROCYTES	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
TFEB	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50

Incoming (34)

Source	Relation	Type	Str
24338664	is	paper	0.90
24338664	belongs to	paper	0.90
SNCA	cross_disease_mechanism_in	gene_or_pathway	0.84
alpha_synuclein	causes	protein	0.72
HAND	associated_with	entity	0.60
ALS	associated_with	entity	0.60
AUTISM	associated_with	entity	0.60
DEPRESSION	associated_with	entity	0.60
EPILEPSY	associated_with	entity	0.60
EPILEPSY	co_discussed	entity	0.50
HUNTINGTON	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
GBA	co_discussed	entity	0.50
LC3	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
CBD	co_discussed	entity	0.50
AUTOPHAGY	contributes_to	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
BLOOD-BRAIN BARRIER	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
CGAS	co_discussed	entity	0.50
FTD	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
DLB	co_discussed	entity	0.50
FRONTOTEMPORAL	co_discussed	entity	0.50
DEPRESSION	co_discussed	entity	0.50
ALPHA-SYNUCLEIN	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
BRAINSTEM	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
CERAMIDE	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SNCA conformer propagation across PD, DLB, and MSA	0.820	multi	Cross-disease neurodegeneration mechanis

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cross-disease neurodegeneration mechanism synthesis

neurodegeneration | 2026-04-28 | 17 hypotheses Top: 0.828

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Iron Dyshomeostasis in MSA Pathogenesis Experiment	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,280,000

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple sys [PMID:9682846]	Unknown	Neuroscience letters	1998
Mutation in the alpha-synuclein gene identified in families with Parkinson's dis [PMID:9197268]	Unknown	Science (New York, N.Y.)	1997
Alpha-synuclein in Lewy bodies. [PMID:9278044]	Unknown	Nature	1997

Debates (1)

Multi-agent debates referencing this entity

Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield

closed · Rounds: 4 · Score: 0.72 · 2026-04-28

Related Research

Hypotheses and analyses mentioning msa in their description or question text

No additional research found

msa

Understanding Entity Pages

Wiki Pages (17)

Striatonigral Degeneration in Multiple System Atrophy

msa-pathophysiology-disease-mechanisms

msa-oligodendrocyte-pathology

msa-cure-roadmap

msa-autonomic-failure-mechanisms

msa-sleep-disordered-breathing

payload-msa-autonomic-dysfunction-therapy

glial-cytoplasmic-inclusions-msa

msa-therapeutic-ideas

msa-imaging-biomarkers

Ramsay Hunt Syndrome

bld-2660-msa-nct05224379

msa

msa-autonomic-failure-mechanism

msa-alpha-synuclein-glial-cytoplasmic-inclusions

msa-pd-alpha-synuclein-strain-comparison

msa-gci-formation-mechanism