Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRAMETINIB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TRAMETINIB |
| Key Genes/Proteins | MEK, BRAF, MAPK |
| Related Diseases | CANCER, ALS |
| Related Pathways | MAPK |
Knowledge base pages for this entity
graph TD
TRAMETINIB["TRAMETINIB"]
TRAMETINIB -->|"inhibits"| MAPK_Pathway["MAPK Pathway"]
TRAMETINIB -->|"inhibits"| MAP2K1["MAP2K1"]
TRAMETINIB -->|"inhibits"| ERK["ERK"]
TRAMETINIB -->|"inhibits"| MEK["MEK"]
TRAMETINIB -->|"inhibits"| Oncogene_Induced_Senescence["Oncogene-Induced Senescence"]
TRAMETINIB -->|"inhibits"| MAPK["MAPK"]
TRAMETINIB -->|"treats"| ALS["ALS"]| Source | Relation | Type | Str |
|---|---|---|---|
| BRAF | inhibits | gene | 0.65 |
| VEMURAFENIB | associated_with | drug | 0.45 |
| DABRAFENIB | associated_with | drug | 0.45 |
| BRAF | associated_with | gene | 0.45 |
| SORAFENIB | associated_with | drug | 0.45 |
| ALS | associated_with | disease | 0.45 |
| MAPK | associated_with | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||