MAP2K1

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP2K1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MAP2K1 encodes MEK1, a dual-specificity kinase critical in the RAS-RAF-MEK-ERK MAPK signaling cascade, with roles in synaptic plasticity, neuronal survival, and neurodegenerative disease pathogenesis

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graph TD
    MAP2K1["<b>MAP2K1</b>"]
    sphingolipid_signaling_pathway(["sphingolipid signaling pathway"])
    MAP2K1 -->|"participates in"| sphingolipid_signaling_pathway
    Als{"Als"}
    MAP2K1 -->|"biomarker for"| Als
    Ms{"Ms"}
    MAP2K1 -->|"biomarker for"| Ms
    MAP2K1 -->|"therapeutic target"| Als
    Cancer{"Cancer"}
    MAP2K1 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    MAP2K1 -->|"associated with"| Tumor
    MAP2K1 -->|"therapeutic target"| Ms
    VCAM1["VCAM1"]
    MAP2K1 -->|"biomarker for"| VCAM1
    LMNA["LMNA"]
    MAP2K1 -->|"biomarker for"| LMNA
    GAPDH["GAPDH"]
    MAP2K1 -->|"biomarker for"| GAPDH
    Sphingolipid(["Sphingolipid"])
    MAP2K1 -->|"biomarker for"| Sphingolipid
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    MAP2K1 -->|"biomarker for"| Unfolded_Protein_Response
    SUST["SUST"]
    SUST -->|"associated with"| MAP2K1
    ENO1["ENO1"]
    ENO1 -->|"biomarker for"| MAP2K1
    BCL2L1["BCL2L1"]
    BCL2L1 -->|"associated with"| MAP2K1
    style MAP2K1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0