protein

TYROBP/DAP12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TYROBP/DAP12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

1Analyses

7Outgoing

8Incoming

0Experiments

5Debates

Summary

Page for TYROBP/DAP12 Protein

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🔬 Protein Info

Gene Symbol	TYROBP/DAP12
Molecular Weight	12 kDa
Amino Acids	10 aa
Pathways	PI3K, MAPK, NF-κB
Associated Diseases	Alzheimer'S Disease, disease
Interactions	SYK, TREM2
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

TYROBP/DAP12 Microglia Signaling Pathway in Alzheimer's Disease

mechanism · 2768 words

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TYROBP/DAP12 Protein

protein · 918 words

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Pathway Diagram

flowchart TD
    N0["TYROBP/DAP12"]
    N1["ALZHEIMER"]
    N0 -->|"associated with"| N1
    N2["Alzheimer'S Disease"]
    N0 -->|"associated with"| N2
    N3["disease"]
    N0 -->|"associated with"| N3
    N4["ALZHEIMER'S"]
    N0 -->|"associated with"| N4
    N5["TREM2"]
    N5 -->|"associated with"| N0
    N6["TYROBP"]
    N6 -->|"associated with"| N0
    N7["DAP12"]
    N7 -->|"associated with"| N0
    N8["microglia"]
    N8 -->|"associated with"| N0
    N5 -->|"causes"| N0
    N6 -->|"causes"| N0
    N7 -->|"causes"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 disease
    class N3 disease
    class N5 gene
    class N6 gene
    class N7 protein

Outgoing (7)

Target	Relation	Type	Str
TREM2	interacts_with	gene	0.90
Aβ amyloidosis	regulates	disease	0.80
SYK	activates	protein	0.70
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50

Incoming (8)

Source	Relation	Type	Str
TREM2	activates	protein	0.90
TREM2	associated_with	gene	0.50
TYROBP	associated_with	gene	0.50
DAP12	associated_with	protein	0.50
microglia	associated_with	cell_type	0.50
TREM2	causes	gene	0.50
TYROBP	causes	gene	0.50
DAP12	causes	protein	0.50