Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ua: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | inhibits | process | 0.95 |
| NF-κB | inhibits | pathway | 0.90 |
| IL-6 | downregulates | protein | 0.90 |
| IL-1Β | downregulates | protein | 0.90 |
| TNF-Α | downregulates | protein | 0.90 |
| Microglial M1 Polarization | inhibits | process | 0.85 |
| Intracerebral Hemorrhage | treats | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plasma ATN biomarkers across AD continuum in Chilean cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Chilean older adults (n=318) w | proposed | N/A |
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.900 | 0.50 | aortic endothelial cells | proposed | $6,550,000 |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Differential GWAS of schizophrenia vs PTSD | exploratory | schizophrenia, post-traumatic | 0.900 | 0.00 | human patients - European ance | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Creation and validation of 3xAD-ChAT-Cre mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | 3xAD-ChAT-Cre transgenic mice | proposed | N/A |
| Development and validation of triple knock-in humanized mice | validation | COVID-19/SARS-CoV-2 infection | 0.900 | 0.00 | Triple knock-in mice expressin | proposed | N/A |
| GTEx brain tissue expression analysis of MAPT/CRHR1 locus | exploratory | schizophrenia, post-traumatic | 0.850 | 0.00 | human brain tissue samples fro | proposed | N/A |
| Microtubule domain analysis in adult axons | exploratory | 0.800 | 0.00 | adult rodent axons | proposed | N/A | |
| Tau depletion effects on microtubule domains in adult axons | exploratory | 0.800 | 0.00 | adult rodent neurons | proposed | N/A | |
| Pharmacokinetic evaluation of humanized mAbs in IgG1-Fc humanized mice | validation | 0.800 | 0.00 | IgG1-Fc humanized hFCGRT trans | proposed | N/A | |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $240,000 |
| s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/ | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $260,000 |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NPH Glymphatic System Interaction Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Vascular Contributions to Alzheimer Disease and Mixed Pathology | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Aquaporin-4 in glymphatic system, and its implication for central nervous system [PMID:36796590] | Peng S, Liu J, Liang C, Yang L, Wang G | Neurobiol Dis | 2023 | 2 |
| Uncommon inflammatory/immune-related myelopathies. [PMID:34715593] | Valencia-Sanchez C, Flanagan EP | J Neuroimmunol | 2021 | 2 |
| Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] | Sehlin D, Hultqvist G, Michno W, Aguilar | J Prev Alzheimers Dis | 2025 | 1 |
| A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy [PMID:40020261] | Ana-Sosa-Batiz F, Verma SK, Shafee N, Mi | EBioMedicine | 2025 | 1 |
| B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. [PMID:38383779] | Afzali AM, Nirschl L, Sie C, Pfaller M, | Nature | 2024 | 1 |
| The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene [PMID:33717213] | Dalakas MC, Spaeth PJ | Ther Adv Neurol Disord | 2021 | 1 |
| Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human [PMID:33025844] | Low BE, Christianson GJ, Lowell E, Qin W | MAbs | 2020 | 1 |
| Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressu [PMID:31959516] | Reeves BC, Karimy JK, Kundishora AJ, Mes | Trends Mol Med | 2020 | 1 |
| Inebilizumab-cdon. [PMID:32936251] | Unknown | American journal of health-sys | 2020 | 1 |
| The glymphatic pathway in neurological disorders. [PMID:30353860] | Rasmussen MK, Mestre H, Nedergaard M | Lancet Neurol | 2018 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Impact of Neonatal Fc Receptor on Transferrin Receptor Antibody Fusion Protein P [PMID:41755010] | ["Oyegbesan A", "Jagadeesan N", "Chandra | Pharmaceutics | 2026 | 0 |
| ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818] | ["Li X", "Huang J", "Zhou Y", "Chen X", | International journal of pharm | 2026 | 0 |
| Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of [PMID:41422555] | Mishra AK, Jain S | ACS Chem Neurosci | 2026 | 0 |
| β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral ed [PMID:41535708] | Yu MJ, Xiong RQ, Wu JW, Li YC, Xie JX et | Acta Pharmacol Sin | 2026 | 0 |
| The association of Alzheimer's disease-related SNPs with mild cognitive impairme [PMID:41606232] | Xie Z, Tu W, Ye XF, Hua L, Zhang X et al | Sci Rep | 2026 | 0 |
| Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] | Akkaoui J, Devadoss D, Rodriguez MD, Ari | Neural Regen Res | 2026 | 0 |
| NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopat [PMID:41650822] | López-Sampere Y, Mengod Soler P, Roca-Pe | Redox Biol | 2026 | 0 |
| Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt [PMID:41665955] | Qi F, Lennon VA, Zhao S, Guo Y, Ding H e | J Clin Invest | 2026 | 0 |
| Genetic Burden and <i>APOE</i> Methylation in a Korean Multi-Generational Alzhei [PMID:41745359] | Eom Je-Hyun; Cho Mu-Yeol; Kim Ji-Won; Ki | Journal of personalized medici | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Ua in their description or question text
Score: 0.732 · neurodegeneration · 2026-04-02
## Mechanistic Overview Aquaporin-4 Polarization Rescue starts from the claim that modulating AQP4 within the disease co
Score: 0.720 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome represen
Score: 0.699 · neurodegeneration · 2026-04-15
## Mechanistic Overview H2: Indole-3-Propionate (IPA) as the Actual Neuroprotective Effector starts from the claim that
Score: 0.680 · neurodegeneration · 2026-04-28
Impaired mitochondrial dynamics and reduced mitophagy represent a shared energy crisis converging on synaptic vulnerabil
Score: 0.670 · neurodegeneration · 2026-04-13
## Mechanistic Overview Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biased Agonism starts from the claim that
Score: 0.668 · neurodegeneration · 2026-04-02
## Mechanistic Overview Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modulation starts from the claim that mo
Score: 0.650 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The molecular foundation of this therapeutic approach centers on the dual functio
Score: 0.644 · neurodegeneration · 2026-04-15
## Mechanistic Overview Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy starts from the claim th
Score: 0.627 · neurodegeneration · 2026-04-02
## Mechanistic Overview Quantum Coherence Disruption in Cellular Communication starts from the claim that modulating TUB
Score: 0.627 · neurodegeneration · 2026-04-04
## Mechanistic Overview Cardiovascular-Neuroinflammatory Dual Targeting starts from the claim that modulating TNF/IL6 wi
Score: 0.625 · neuroscience · 2026-04-22
**Molecular Mechanism and Rationale** Galectin-3 (LGALS3) functions as a critical molecular sensor and platform orchest
Score: 0.620 · neurodegeneration · 2026-04-22
## Mechanistic Overview Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau Release from Hypersynchronized Circ
Score: 0.604 · neurodegeneration · 2026-04-15
## Mechanistic Overview DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against Tau-Induced Destabilization starts fr